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Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.


  
Structural insight into nucleosome transcription by RNA polymerase II with elongation factors 期刊论文
SCIENCE, 2019, 363 (6428) : 744-+
作者:  Ehara, Haruhiko;  Kujirai, Tomoya;  Fujino, Yuka;  Shirouzu, Mikako;  Kurumizaka, Hitoshi;  Sekine, Shun-ichi
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Tracking emissions in the US electricity system 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51) : 25497-25502
作者:  Jacques A. de Chalendar;  John Taggart;  and Sally M. Benson
收藏  |  浏览/下载：8/0  |  提交时间：2020/04/16
carbon intensity of electricity  renewable energy policy  electricity system emissions factors  emissions embodied in electricity exchanges  
Coherent encoding of subjective spatial position in visual cortex and hippocampus 期刊论文
NATURE, 2018, 562 (7725) : 124-+
作者:  Saleem, Aman B.;  Diamanti, E. Mika;  Fournier, Julien;  Harris, Kenneth D.;  Carandini, Matteo
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq 期刊论文
SCIENCE, 2017, 358 (6370) : 1622-1626
作者:  Medaglia, Chiara;  Giladi, Amir;  Stoler-Barak, Liat;  De Giovanni, Marco;  Salame, Tomer Meir;  Biram, Adi;  David, Eyal;  Li, Hanjie;  Iannacone, Matteo;  Shulman, Ziv;  Amit, Ido
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
Historical climate controls soil respiration responses to current soil moisture 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (24) : 6322-6327
作者:  Hawkes, Christine V.;  Waring, Bonnie G.;  Rocca, Jennifer D.;  Kivlin, Stephanie N.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
microbial  climate change  precipitation  legacies  
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages 期刊论文
NATURE, 2017, 543 (7645) : 428-+
作者:  Guerriero, Jennifer L.;  Sotayo, Alaba;  Ponichtera, Holly E.;  Castrillon, Jessica A.;  Pourzia, Alexandra L.;  Schad, Sara;  Johnson, Shawn F.;  Carrasco, Ruben D.;  Lazo, Suzan;  Bronson, Roderick T.;  Davis, Scott P.;  Lobera, Mercedes;  Nolan, Michael A.;  Letai, Anthony
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09