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Low thermal conductivity of iron-silicon alloys at Earth's core conditions with implications for the geodynamo 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Hsieh, Wen-Pin;  Goncharov, Alexander F.;  Labrosse, Stephane;  Holtgrewe, Nicholas;  Lobanov, Sergey S.;  Chuvashova, Irina;  Deschamps, Frederic;  Lin, Jung-Fu
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/06
Evaluation of an Improved Convective Triggering Function: Observational Evidence and SCM Tests 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (11)
作者:  Wang, Yi-Chi;  Xie, Shaocheng;  Tang, Shuaiqi;  Lin, Wuyin
收藏  |  浏览/下载：10/0  |  提交时间：2020/08/18
convection trigger  convection  diurnal cycle of precipitation  E3SM  precipitation  single-column model  
Controls on surface water carbonate chemistry along North American ocean margins 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Cai, Wei-Jun;  Xu, Yuan-Yuan;  Feely, Richard A.;  Wanninkhof, Rik;  Jonsson, Bror;  Alin, Simone R.;  Barbero, Leticia;  Cross, Jessica N.;  Azetsu-Scott, Kumiko;  Fassbender, Andrea J.;  Carter, Brendan R.;  Jiang, Li-Qing;  Pepin, Pierre;  Chen, Baoshan;  Hussain, Najid;  Reimer, Janet J.;  Xue, Liang;  Salisbury, Joseph E.;  Martin Hernandez-Ayon, Jose;  Langdon, Chris;  Li, Qian;  Sutton, Adrienne J.;  Chen, Chen-Tung A.;  Gledhill, Dwight K.
收藏  |  浏览/下载：14/0  |  提交时间：2020/06/09
Past and future decline of tropical pelagic biodiversity 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (23) : 12891-12896
作者:  Yasuhara, Moriaki;  Wei, Chih-Lin;  Kucera, Michal;  Costello, Mark J.;  Tittensor, Derek P.;  Kiessling, Wolfgang;  Bonebrake, Timothy C.;  Tabor, Clay R.;  Feng, Ran;  Baselga, Andres;  Kretschmer, Kerstin;  Kusumoto, Buntarou;  Kubota, Yasuhiro
收藏  |  浏览/下载：12/0  |  提交时间：2020/06/01
latitudinal diversity gradients  planktonic foraminifera  temperature  Last Glacial Maximum  climate change  
Causal effects of population dynamics and environmental changes on spatial variability of marine fishes 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wang, Jheng-Yu;  Kuo, Ting-Chun;  Hsieh, Chih-hao
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/01
Effect of Water on Lattice Thermal Conductivity of Ringwoodite and Its Implications for the Thermal Evolution of Descending Slabs 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Marzotto, Enrico;  Hsieh, Wen-Pin;  Ishii, Takayuki;  Chao, Keng-Hsien;  Golabek, Gregor J.;  Thielmann, Marcel;  Ohtani, Eiji
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/25
hydrous ringwoodite  lattice thermal conductivity  mantle transition zone  water cycle  
Characteristics of the Prolonged El Nino Events During 1960-2020 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Lee, Chung-Wei;  Tseng, Yu-Heng;  Sui, Chung-Hsiung;  Zheng, Fei;  Wu, Erh-Tung
收藏  |  浏览/下载：8/0  |  提交时间：2020/05/25
Time-Lapse Imaging of Coseismic Ruptures for the 2019 Ridgecrest Earthquakes Using Multiazimuth Backprojection With Regional Seismic Data and a 3-D Crustal Velocity Model 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Yang, Jidong;  Zhu, Hejun;  Lumley, David
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/02
earthquake rupture  backprojection  coseismic rupture  
Spatiotemporal Seismic Structure Variations Associated With the 2018 Kilauea Eruption Based on Temporary Dense Geophone Arrays 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Wu, Sin-Mei;  Lin, Fan-Chi;  Farrell, Jamie;  Shiro, Brian;  Karlstrom, Leif;  Okubo, Paul;  Koper, Keith
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Kilauea volcano  magma pressurization  summit collapse  seismic interferometry  dike intrusion  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.