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Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.


  
Carbon budgets of wetland ecosystems in China 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (6) : 2061-2076
作者:  Xiao, Derong;  Deng, Lei;  Kim, Dong-Gill;  Huang, Chunbo;  Tian, Kun
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/26
carbon emission  carbon sequestration  carbon stock  carbon uptake  climate  wetland  
Structural insight into nucleosome transcription by RNA polymerase II with elongation factors 期刊论文
SCIENCE, 2019, 363 (6428) : 744-+
作者:  Ehara, Haruhiko;  Kujirai, Tomoya;  Fujino, Yuka;  Shirouzu, Mikako;  Kurumizaka, Hitoshi;  Sekine, Shun-ichi
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Tracking emissions in the US electricity system 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51) : 25497-25502
作者:  Jacques A. de Chalendar;  John Taggart;  and Sally M. Benson
收藏  |  浏览/下载：8/0  |  提交时间：2020/04/16
carbon intensity of electricity  renewable energy policy  electricity system emissions factors  emissions embodied in electricity exchanges  
Climate and plant controls on soil organic matter in coastal wetlands 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (11) : 5361-5379
作者:  Osland, Michael J.;  Gabler, Christopher A.;  Grace, James B.;  Day, Richard H.;  McCoy, Meagan L.;  McLeod, Jennie L.;  From, Andrew S.;  Enwright, Nicholas M.;  Feher, Laura C.;  Stagg, Camille L.;  Hartley, Stephen B.
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09
carbon  climate change  coastal wetland  mangrove  plant productivity  precipitation  salinity  salt marsh  soil organic matter  temperature  
Climatic, topographic, and anthropogenic factors determine connectivity between current and future climate analogs in North America 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (11) : 5318-5331
作者:  Carroll, Carlos;  Parks, Sean A.;  Dobrowski, Solomon Z.;  Roberts, David R.
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/09
climate change adaptation  connectivity  conservation planning  graph theory  protected areas  refugia  
Coherent encoding of subjective spatial position in visual cortex and hippocampus 期刊论文
NATURE, 2018, 562 (7725) : 124-+
作者:  Saleem, Aman B.;  Diamanti, E. Mika;  Fournier, Julien;  Harris, Kenneth D.;  Carandini, Matteo
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Quantifying climate-growth relationships at the stand level in a mature mixed-species conifer forest 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (8) : 3587-3602
作者:  Teets, Aaron;  Fraver, Shawn;  Weiskittel, Aaron R.;  Hollinger, David Y.
收藏  |  浏览/下载：9/0  |  提交时间：2019/04/09
biomass increment  canopy position  climate change  dendrochronology  forest carbon cycle  Howland Forest  tree growth response  
Challenging a 15-year-old claim: The North Atlantic Oscillation index as a predictor of spring migration phenology of birds 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (4) : 1523-1537
作者:  Haest, Birgen;  Hueppop, Ommo;  Bairlein, Franz
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/09
bird migration  climate change  large-scale climate indices  meta-analysis  Northern Hemisphere  short-distance migration  time window analysis  trans-Saharan migrants  
Why decadal to century timescale palaeoclimate data are needed to explain present-day patterns of biological diversity and change 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (3) : 1371-1381
作者:  Fordham, Damien A.;  Saltre, Frederik;  Brown, Stuart C.;  Mellin, Camille;  Wigley, Tom M. L.
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09
climate dissimilarity  climate stability  climate velocity  growing degree days  novel climates  palaeoecology  phenology feedbacks  quaternary climate change