GSTDTAP

浏览/检索结果: 共26条,第1-10条 帮助

限定条件                        
已选(0)清除 条数/页:   排序方式:
Leaf senescence exhibits stronger climatic responses during warm than during cold autumns 期刊论文
NATURE CLIMATE CHANGE, 2020
作者:  Chen, Lei;  Hanninen, Heikki;  Rossi, Sergio;  Smith, Nicholas G.;  Pau, Stephanie;  Liu, Zhiyong;  Feng, Guanqiao;  Gao, Jie;  Liu, Jianquan
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/09
Arctic freshwater fish productivity and colonization increase with climate warming 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (5) : 428-+
作者:  Campana, Steven E.;  Casselman, John M.;  Jones, Cynthia M.;  Black, Gerald;  Barker, Oliver;  Evans, Marlene;  Guzzo, Matthew M.;  Kilada, Raouf;  Muir, Andrew M.;  Perry, Robert
收藏  |  浏览/下载:6/0  |  提交时间:2020/05/13
Dopamine D2 receptors in discrimination learning and spine enlargement 期刊论文
NATURE, 2020, 579 (7800) : 555-+
作者:  Luo, Zhaochu;  Hrabec, Ales;  Dao, Trong Phuong;  Sala, Giacomo;  Finizio, Simone;  Feng, Junxiao;  Mayr, Sina;  Raabe, Joerg;  Gambardella, Pietro;  Heyderman, Laura J.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Detection of dopamine dips by neurons that express dopamine D2 receptors in the striatum is used to refine generalized reward conditioning mediated by dopamine D1 receptors.


Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia(1,2). High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning(3-5). However, the nature and cellular basis of D2R-dependent behaviour are unclear. Here we show that tone reward conditioning induces marked stimulus generalization in a manner that depends on dopamine D1 receptors (D1Rs) in the nucleus accumbens (NAc) of mice, and that discrimination learning refines the conditioning using a dopamine dip. In NAc slices, a narrow dopamine dip (as short as 0.4 s) was detected by D2Rs to disinhibit adenosine A(2A) receptor (A(2A)R)-mediated enlargement of dendritic spines in D2R-expressing spiny projection neurons (D2-SPNs). Plasticity-related signalling by Ca2+/calmodulin-dependent protein kinase II and A(2A)Rs in the NAc was required for discrimination learning. By contrast, extinction learning did not involve dopamine dips or D2-SPNs. Treatment with methamphetamine, which dysregulates dopamine signalling, impaired discrimination learning and spine enlargement, and these impairments were reversed by a D2R antagonist. Our data show that D2Rs refine the generalized reward learning mediated by D1Rs.


  
Clam feeding plasticity reduces herbivore vulnerability to ocean warming and acidification 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (2) : 162-+
作者:  Van Colen, Carl;  Ong, Ee Zin;  Briffa, Mark;  Wethey, David S.;  Abatih, Emmanuel;  Moens, Tom;  Woodin, Sarah A.
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Adapt or die-Response of large herbivores to environmental changes in Europe during the Holocene 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (9) : 2915-2930
作者:  Hofman-Kaminska, Emilia;  Bocherens, Herve;  Drucker, Dorothee G.;  Fyfe, Ralph M.;  Guminski, Witold;  Makowiecki, Daniel;  Pacher, Martina;  Piliciauskiene, Giedre;  Samojlik, Tomasz;  Woodbridge, Jessie;  Kowalczyk, Rafal
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Alces alces  aurochs  Bison bonasus  Bos primigenius  European bison  foraging ecology  moose  stable isotopes  
The Adaptive Sex in Stressful Environments 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2019, 34 (7) : 628-640
作者:  Geffroy, Benjamin;  Douhard, Mathieu
收藏  |  浏览/下载:2/0  |  提交时间:2019/11/27
A cerebellar mechanism for learning prior distributions of time intervals 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Narain, Devika;  Remington, Evan D.;  De Zeeuw, Chris I.;  Jazayeri, Mehrdad
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Temporal coherence structure rapidly shapes neuronal interactions 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Lu, Kai;  Xu, Yanbo;  Yin, Pingbo;  Oxenham, Andrew J.;  Fritz, Jonathan B.;  Shamma, Shihab A.
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
Somatosensory alpha oscillations gate perceptual learning efficiency 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Brickwedde, Marion;  Krueger, Marie C.;  Dinse, Hubert R.
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
New dimensions for brain mapping 期刊论文
SCIENCE, 2018, 362 (6418) : 994-995
作者:  Assaf, Yaniv
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27