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International evaluation of an AI system for breast cancer screening 期刊论文
NATURE, 2020, 577 (7788) : 89-+
作者:  McKinney, Scott Mayer;  Sieniek, Marcin;  Godbole, Varun;  Godwin, Jonathan;  Antropova, Natasha;  Ashrafian, Hutan;  Back, Trevor;  Chesus, Mary;  Corrado, Greg C.;  Darzi, Ara;  Etemadi, Mozziyar;  Garcia-Vicente, Florencia;  Gilbert, Fiona J.;  Halling-Brown, Mark;  Hassabis, Demis;  Jansen, Sunny;  Karthikesalingam, Alan;  Kelly, Christopher J.;  King, Dominic;  Ledsam, Joseph R.;  Melnick, David;  Mostofi, Hormuz;  Peng, Lily;  Reicher, Joshua Jay;  Romera-Paredes, Bernardino;  Sidebottom, Richard;  Suleyman, Mustafa;  Tse, Daniel;  Young, Kenneth C.;  De Fauw, Jeffrey;  Shetty, Shravya
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Screening mammography aims to identify breast cancer at earlier stages of the disease, when treatment can be more successful(1). Despite the existence of screening programmes worldwide, the interpretation of mammograms is affected by high rates of false positives and false negatives(2). Here we present an artificial intelligence (AI) system that is capable of surpassing human experts in breast cancer prediction. To assess its performance in the clinical setting, we curated a large representative dataset from the UK and a large enriched dataset from the USA. We show an absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negatives. We provide evidence of the ability of the system to generalize from the UK to the USA. In an independent study of six radiologists, the AI system outperformed all of the human readers: the area under the receiver operating characteristic curve (AUC-ROC) for the AI system was greater than the AUC-ROC for the average radiologist by an absolute margin of 11.5%. We ran a simulation in which the AI system participated in the double-reading process that is used in the UK, and found that the AI system maintained non-inferior performance and reduced the workload of the second reader by 88%. This robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening.


  
Using Particle Tracking to Understand Flow Paths, Age Distributions, and the Paradoxical Origins of the Inverse Storage Effect in an Experimental Catchment 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (4)
作者:  Wilusz, D. C.;  Harman, C. J.;  Ball, W. P.;  Maxwell, R. M.;  Buda, A. R.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
integrated hydrology model  transit time model  runoff generation mechanisms  particle tracking  storage selection functions  
Operation of a silicon quantum processor unit cell above one kelvin 期刊论文
NATURE, 2020, 580 (7803) : 350-+
作者:  Han, Kyuho;  Pierce, Sarah E.;  Li, Amy;  Spees, Kaitlyn;  Anderson, Grace R.;  Seoane, Jose A.;  Lo, Yuan-Hung;  Dubreuil, Michael;  Olivas, Micah;  Kamber, Roarke A.;  Wainberg, Michael;  Kostyrko, Kaja;  Kelly, Marcus R.;  Yousefi, Maryam;  Simpkins, Scott W.;  Yao, David
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)(1-3). For most solid-state qubit technologies-for example, those using superconducting circuits or semiconductor spins-scaling poses a considerable challenge because every additional qubit increases the heat generated, whereas the cooling power of dilution refrigerators is severely limited at their operating temperature (less than 100 millikelvin)(4-6). Here we demonstrate the operation of a scalable silicon quantum processor unit cell comprising two qubits confined to quantum dots at about 1.5 kelvin. We achieve this by isolating the quantum dots from the electron reservoir, and then initializing and reading the qubits solely via tunnelling of electrons between the two quantum dots(7-9). We coherently control the qubits using electrically driven spin resonance(10,11) in isotopically enriched silicon(12 28)Si, attaining single-qubit gate fidelities of 98.6 per cent and a coherence time of 2 microseconds during '  hot'  operation, comparable to those of spin qubits in natural silicon at millikelvin temperatures(13-16). Furthermore, we show that the unit cell can be operated at magnetic fields as low as 0.1 tesla, corresponding to a qubit control frequency of 3.5 gigahertz, where the qubit energy is well below the thermal energy. The unit cell constitutes the core building block of a full-scale silicon quantum computer and satisfies layout constraints required by error-correction architectures(8),(17). Our work indicates that a spin-based quantum computer could be operated at increased temperatures in a simple pumped He-4 system (which provides cooling power orders of magnitude higher than that of dilution refrigerators), thus potentially enabling the integration of classical control electronics with the qubit array(18,19).


  
A new risk probability calculation method for urban ecological risk assessment 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (2)
作者:  Liu, Changfeng;  Chen, Weiping;  Hou, Ying;  Ma, Lingchao
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
urban ecological risk assessment  risk probability  Monte Carlo simulation  copula function  water environment  
Analysis and Modeling of Precipitation Intermittency by Compound Markov-DARMA Models 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (2)
作者:  Wiuff, Rasmus
收藏  |  浏览/下载:0/0  |  提交时间:2020/07/02
Intermittency  Precipitation  Modelling  Compound models  Binary models  
Optimal configuration and resolution for the first convection-permitting ensemble of climate projections over the United Kingdom 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Fosser, Giorgia;  Kendon, Elizabeth;  Chan, Steven;  Lock, Adrian;  Roberts, Nigel;  Bush, Mike
收藏  |  浏览/下载:6/0  |  提交时间:2020/02/17
climate  convection-permitting models  physical process configuration  rainfall  UKCP18 ensemble  
"Surface," "satellite" or "simulation": Mapping intra-urban microclimate variability in a desert city 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Zhou, Bin;  Kaplan, Shai;  Peeters, Aviva;  Kloog, Itai;  Erell, Evyatar
收藏  |  浏览/下载:4/0  |  提交时间:2020/02/17
A coherent quantum annealer with Rydberg atoms 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Glaetzle, A. W.;  van Bijnen, R. M. W.;  Zoller, P.;  Lechner, W.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
The Plasma Nature of Lightning Channels and the Resulting Nonlinear Resistance 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (16) : 9442-9463
作者:  da Silva, C. L.;  Sonnenfeld, R. G.;  Edens, H. E.;  Krehbiel, P. R.;  Quick, M. G.;  Koshak, W. J.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
lightning  plasma  return stroke  streamer  leader  arc  
Agent-Based Modeling for bioenergy sustainability assessment 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 188: 54-63
作者:  Rouleau, Mark;  Zupko, Robert
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Sustainability assessment  Bioenergy  Agent-Based Modeling  Woody biomass harvesting  Smallholders  Voluntary incentive programs