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FACT caught in the act of manipulating the nucleosome 期刊论文
NATURE, 2020, 577 (7790) : 426-+
作者:  Shen, Helen
收藏  |  浏览/下载：4/0  |  提交时间：2020/07/03

The organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes in eukaryotes. The histone chaperone known as '  facilitates chromatin transcription'  (FACT(1)) (consisting of subunits SPT16 and SSRP1) promotes both disassembly and reassembly of nucleosomes during gene transcription, DNA replication and DNA repair(2). However, the mechanism by which FACT causes these opposing outcomes is unknown. Here we report two cryo-electron-microscopic structures of human FACT in complex with partially assembled subnucleosomes, with supporting biochemical and hydrogen-deuterium exchange data. We find that FACT is engaged in extensive interactions with nucleosomal DNA and all histone variants. The large DNA-binding surface on FACT appears to be protected by the carboxy-terminal domains of both of its subunits, and this inhibition is released by interaction with H2A-H2B, allowing FACT-H2A-H2B to dock onto a complex containing DNA and histones H3 and H4 (ref. (3)). SPT16 binds nucleosomal DNA and tethers H2A-H2B through its carboxy-terminal domain by acting as a placeholder for DNA. SSRP1 also contributes to DNA binding, and can assume two conformations, depending on whether a second H2A-H2B dimer is present. Our data suggest a compelling mechanism for how FACT maintains chromatin integrity during polymerase passage, by facilitating removal of the H2A-H2B dimer, stabilizing intermediate subnucleosomal states and promoting nucleosome reassembly. Our findings reconcile discrepancies regarding the many roles of FACT and underscore the dynamic interactions between histone chaperones and nucleosomes.


  
The mechanisms and meteorological drivers of the summertime ozone-temperature relationship 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (20) : 13367-13381
作者:  Porter, William C.;  Heald, Colette L.
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Changes in Fire Activity in Africa from 2002 to 2016 and Their Potential Drivers 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (13) : 7643-7653
作者:  Zubkova, Maria;  Boschetti, Luigi;  Abatzoglou, John T.;  Giglio, Louis
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Desert Dust, Industrialization, and Agricultural Fires: Health Impacts of Outdoor Air Pollution in Africa 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (7) : 4104-4120
作者:  Bauer, Susanne E.;  Im, Ulas;  Mezuman, Keren;  Gao, Chloe Y.
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/26
Human land use promotes the abundance and diversity of exotic species on Caribbean islands 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (10) : 4784-4796
作者:  Jesse, Wendy A. M.;  Behm, Jocelyn E.;  Helmus, Matthew R.;  Ellers, Jacintha
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
environmental filtering  functional trait diversity  habitat structure  Lesser Antilles  native and exotic species  reptiles  squamates  tropics  urbanization  
Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Zhang, Qin;  Bai, Baoling;  Mei, Xinyu;  Wan, Chunlei;  Cao, Haiyan;  Li, Dan;  Wang, Shan;  Zhang, Min;  Wang, Zhigang;  Wu, Jianxin;  Wang, Hongyan;  Huo, Junsheng;  Ding, Gangqiang;  Zhao, Jianyuan;  Xie, Qiu;  Wang, Li;  Qiu, Zhiyong;  Zhao, Shiming;  Zhang, Ting
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Associations between Living Near Water and Risk of Mortality among Urban Canadians 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2018, 126 (7)
作者:  Crouse, Dan L.;  Balram, Adele;  Hystad, Perry;  Pinault, Lauren;  van den Bosch, Matilda;  Chen, Hong;  Rainham, Daniel;  Thomson, Errol M.;  Close, Christopher H.;  van Donkelaar, Aaron;  Martin, Randall V.;  Menard, Richard;  Robichaud, Alain;  Villeneuve, Paul J.
收藏  |  浏览/下载：18/0  |  提交时间：2019/04/09
Climate warming is associated with smaller body size and shorter lifespans in moose near their southern range limit 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (6) : 2488-2497
作者:  Hoy, Sarah R.;  Peterson, Rolf O.;  Vucetich, John A.
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/09
Alces alces  climate change  density dependence  early life conditions  growth  phenotypic change  predation  winter temperatures  
Doom and gloom versus optimism: An assessment of ocean-related US science journalism (2001-2015) 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2018, 50: 142-148
作者:  Johns, Lisa N.;  Jacquet, Jennifer
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/09
oceans  calamities  doom and gloom  media content analysis  optimism  
Causes and Probability of Occurrence of Extreme Precipitation Events like Chennai 2015 期刊论文
JOURNAL OF CLIMATE, 2018, 31 (10) : 3831-3848
作者:  Krishnamurthy, Lakshmi;  Vecchi, Gabriel A.;  Yang, Xiaosong;  van der Wiel, Karin;  Balaji, V.;  Kapnick, Sarah B.;  Jia, Liwei;  Zeng, Fanrong;  Paffendorf, Karen;  Underwood, Seth
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09
Indian Ocean  Atmosphere-ocean interaction  El Nino  Extreme events  Flood events  Interannual variability