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A Synthesis Inversion to Constrain Global Emissions of Two Very Short Lived Chlorocarbons: Dichloromethane, and Perchloroethylene 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (12)
作者:  Claxton, Tom;  39;Doherty, Simon
收藏  |  浏览/下载:13/0  |  提交时间:2020/08/18
vsls  inversion  emissions  dichloromethane  perchloroethylene  montreal protocol  
Characterizing disproportionality in facility-level toxic releases in US manufacturing, 1998-2012 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (6)
作者:  Collins, M.;  Pulver, S.;  Hill, D.;  Manski, B.
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
disproportionality  US manufacturing  industrial pollution  
Lipid Biomarker Record Documents Hydroclimatic Variability of the Mississippi River Basin During the Common Era 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Munoz, Samuel E.;  Porter, Trevor J.;  Bakkelund, Aleesha;  Nusbaumer, Jesse;  Dee, Sylvia G.;  Hamilton, Brynnydd;  Giosan, Liviu;  Tierney, Jessica E.
收藏  |  浏览/下载:10/0  |  提交时间:2020/06/01
lipid biomarker  leaf wax  brGDGT  Common Era  paleoclimate  hydroclimate  
Abundant Spontaneous and Dynamically Triggered Submarine Landslides in the Gulf of Mexico 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Fan, Wenyuan;  McGuire, Jeffrey J.;  Shearer, Peter M.
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/20
Gulf of Mexico  Submarine Landslides  Landslides  Surface waves  Dynamic triggering  
Where Do Cold Air Outbreaks Occur, and How Have They Changed Over Time? 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Smith, Erik T.;  Sheridan, Scott C.
收藏  |  浏览/下载:7/0  |  提交时间:2020/05/20
cold air outbreaks  extreme cold events  climate change  polar outbreak  temperature trends  ERA5  
Localization and delocalization of light in photonic moire lattices 期刊论文
NATURE, 2020, 577 (7788) : 42-+
作者:  Wang, Peng;  Zheng, Yuanlin;  Chen, Xianfeng;  Huang, Changming;  Kartashov, Yaroslav V.;  Torner, Lluis;  Konotop, Vladimir V.;  Ye, Fangwei
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Moire lattices consist of two superimposed identical periodic structures with a relative rotation angle. Moire lattices have several applications in everyday life, including artistic design, the textile industry, architecture, image processing, metrology and interferometry. For scientific studies, they have been produced using coupled graphene-hexagonal boron nitride monolayers(1,2), graphene-graphene layers(3,4) and graphene quasicrystals on a silicon carbide surface(5). The recent surge of interest in moire lattices arises from the possibility of exploring many salient physical phenomena in such systems  examples include commensurable-incommensurable transitions and topological defects(2), the emergence of insulating states owing to band flattening(3,6), unconventional superconductivity(4) controlled by the rotation angle(7,8), the quantum Hall effect(9), the realization of non-Abelian gauge potentials(10) and the appearance of quasicrystals at special rotation angles(11). A fundamental question that remains unexplored concerns the evolution of waves in the potentials defined by moire lattices. Here we experimentally create two-dimensional photonic moire lattices, which-unlike their material counterparts-have readily controllable parameters and symmetry, allowing us to explore transitions between structures with fundamentally different geometries (periodic, general aperiodic and quasicrystal). We observe localization of light in deterministic linear lattices that is based on flatband physics(6), in contrast to previous schemes based on light diffusion in optical quasicrystals(12), where disorder is required(13) for the onset of Anderson localization(14) (that is, wave localization in random media). Using commensurable and incommensurable moire patterns, we experimentally demonstrate the twodimensional localization-delocalization transition of light. Moire lattices may feature an almost arbitrary geometry that is consistent with the crystallographic symmetry groups of the sublattices, and therefore afford a powerful tool for controlling the properties of light patterns and exploring the physics of periodic-aperiodic phase transitions and two-dimensional wavepacket phenomena relevant to several areas of science, including optics, acoustics, condensed matter and atomic physics.


  
IT MIGHT BECOME QUICKER AND EASIER TO TRIAL DRUGS 期刊论文
NATURE, 2020, 582 (7811) : 172-172
作者:  Cathomas, Flurin;  Russo, Scott J.
收藏  |  浏览/下载:4/0  |  提交时间:2020/07/03
Characteristic and Spatiotemporal Variation of Air Pollution in Northern China Based on Correlation Analysis and Clustering Analysis of Five Air Pollutants 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (8)
作者:  Tian, Dayong;  Fan, Junhui;  Jin, Hangbiao;  Mao, Haichen;  Geng, Dan;  Hou, Shaogang;  Zhang, Peng;  Zhang, Yifeng
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
PM2  5  Ozone  Air pollution  Northern China  Spatiotemporal variation  
Kenyan tea is made with heat and water: how will climate change influence its yield? 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (4)
作者:  Rigden, A. J.;  Ongoma, V;  Huybers, P.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
tea yield  agriculture  climate change  water balance  soil moisture  
Multispecific drugs herald a new era of biopharmaceutical innovation 期刊论文
NATURE, 2020, 580 (7803) : 329-338
作者:  Gallego, Laura D.;  Schneider, Maren;  Mittal, Chitvan;  Romanauska, Anete;  Carrillo, Ricardo M. Gudino;  Schubert, Tobias;  Pugh, B. Franklin;  Koehler, Alwin
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century, coincident with marketing of aspirin-a signature event in the history of modern drug development. Although the archetypal discovery process did not change markedly in the first seven decades of the industry, the past fifty years have seen two successive waves of transformative innovation in the development of drug molecules: the rise of '  rational drug discovery'  methodology in the 1970s, followed by the invention of recombinant protein-based therapeutic agents in the 1980s. An incipient fourth wave is the advent of multispecific drugs. The successful development of prospectively designed multispecific drugs has the potential to reconfigure our ideas of how target-based therapeutic molecules can work, and what it is possible to achieve with them. Here I review the two major classes of multispecific drugs: those that enrich a therapeutic agent at a particular site of action and those that link a therapeutic target to a biological effector. The latter class-being freed from the constraint of having to directly modulate the target upon binding-may enable access to components of the proteome that currently cannot be targeted by drugs.