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The Impact of Dams on Design Floods in the Conterminous US 期刊论文
WATER RESOURCES RESEARCH, 2020, 56 (3)
作者:  Zhao, Gang;  Bates, Paul;  Neal, Jeffrey
收藏  |  浏览/下载：4/0  |  提交时间：2020/07/02
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.


  
Multiorder Hydrologic Position in the Conterminous United States: A Set of Metrics in Support of Groundwater Mapping at Regional and National Scales 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (12) : 11188-11207
作者:  Belitz, Kenneth;  Moore, Richard B.;  Arnold, Terri L.;  Sharpe, Jennifer B.;  Starn, J. J.
收藏  |  浏览/下载：11/0  |  提交时间：2020/02/16
hydrology  groundwater  machine learning  mapping  GIS  
Strong habitat and weak genetic effects shape the lifetime reproductive success in a wild clownfish population 期刊论文
ECOLOGY LETTERS, 2020, 23 (2) : 265-273
作者:  Salles, Oceane C.;  Almany, Glenn R.;  Berumen, Michael L.;  Jones, Geoffrey P.;  Saenz-Agudelo, Pablo;  Srinivasan, Maya;  Thorrold, Simon R.;  Pujol, Benoit;  Planes, Serge
收藏  |  浏览/下载：5/0  |  提交时间：2020/07/02
Adaptation  additive genetic variation  environmental effects  evolvability  heritability  maternal effects  multi-generational pedigree  selection  
An Adjoint Sensitivity Model for Steady-State Sequentially Coupled Radionuclide Transport in Porous Media 期刊论文
WATER RESOURCES RESEARCH, 2019
作者:  Hayek, Mohamed;  RamaRao, Banda S.;  Lavenue, Marsh
收藏  |  浏览/下载：6/0  |  提交时间：2020/02/16
sensitivity analysis  adjoint method  analytical solutions  radionuclide transport  
Social drivers of rural forest dynamics: A multi-scale approach combining ethnography, geomatic and mental model analysis 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 188: 132-142
作者:  Blanco, Julien;  Sourdril, Anne;  Deconchat, Marc;  Ladet, Sylvie;  Andrieu, Emilie
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Non-industrial private forest  Trees outside forests  Ecosystem services  Local ecological knowledge  Agroforestry landscape  Social representations  
Carbon budgets of wetland ecosystems in China 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (6) : 2061-2076
作者:  Xiao, Derong;  Deng, Lei;  Kim, Dong-Gill;  Huang, Chunbo;  Tian, Kun
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/26
carbon emission  carbon sequestration  carbon stock  carbon uptake  climate  wetland  
Spatial-Temporal Variation of Lake Surface Water Temperature and Its Driving Factors in Yunnan-Guizhou Plateau 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (6) : 4688-4703
作者:  Yang, Kun;  Yu, Zhenyu;  Luo, Yi;  Zhou, Xiaolu;  Shang, Chunxue
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/26
lake surface water temperature  plateau lake  lake type  climate warming  urbanization  K-Means clustering method  
Exploring the Head Versus Tail-End Dichotomy on Yield and Farm Incomes in Smallholder Irrigation Schemes in Tanzania 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (5) : 4322-4342
作者:  Manero, Ana;  Wheeler, Sarah Ann;  Zuo, Alec;  Mdemu, Makarius
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/26
irrigation  agricultural development  water distribution  inequality  incomes  yields  
Structural insight into nucleosome transcription by RNA polymerase II with elongation factors 期刊论文
SCIENCE, 2019, 363 (6428) : 744-+
作者:  Ehara, Haruhiko;  Kujirai, Tomoya;  Fujino, Yuka;  Shirouzu, Mikako;  Kurumizaka, Hitoshi;  Sekine, Shun-ichi
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27