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A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
Demonstration of cooling by the Muon Ionization Cooling Experiment 期刊论文
NATURE, 2020, 578 (7793) : 53-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such '  tertiary'  beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton-antilepton collisions at extremely high energies and provide well characterized neutrino beams(1-6). Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness(7,8). Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect(9-11). The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced wfootprint(6).


  
Northward range expansion in spring-staging barnacle geese is a response to climate change and population growth, mediated by individual experience 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (11) : 3680-3693
作者:  Tombre, Ingunn M.;  Oudman, Thomas;  Shimmings, Paul;  Griffin, Larry;  Prop, Jouke
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
age effects  dynamic strategies  explorative behaviour  food quality  population increase  range shift  spring migration  
Archaeological assessment reveals Earth's early transformation through land use 期刊论文
SCIENCE, 2019, 365 (6456) : 897-+
作者:  Stephens, Lucas;  Fuller, Dorian;  Boivin, Nicole;  Rick, Torben;  Gauthier, Nicolas;  Kay, Andrea;  Marwick, Ben;  Armstrong, Chelsey Geralda Denise;  Barton, C. Michael;  Denham, Tim;  Douglass, Kristina;  Driver, Jonathan;  Janz, Lisa;  Roberts, Patrick;  Rogers, J. Daniel;  Thakar, Heather;  Altaweel, Mark;  Johnson, Amber L.;  Sampietro Vattuone, Maria Marta;  Aldenderfer, Mark;  Archila, Sonia;  Artioli, Gilberto;  Bale, Martin T.;  Beach, Timothy;  Borrell, Ferran;  Braje, Todd;  Buckland, Philip I.;  Jimenez Cano, Nayeli Guadalupe;  Capriles, Jose M.;  Diez Castillo, Agustin;  Cilingiroglu, Ciler;  Cleary, Michelle Negus;  Conolly, James;  Coutros, Peter R.;  Covey, R. Alan;  Cremaschi, Mauro;  Crowther, Alison;  Der, Lindsay;  di Lernia, Savino;  Doershuk, John F.;  Doolittle, William E.;  Edwards, Kevin J.;  Erlandson, Jon M.;  Evans, Damian;  Fairbairn, Andrew;  Faulkner, Patrick;  Feinman, Gary;  Fernandes, Ricardo;  Fitzpatrick, Scott M.;  Fyfe, Ralph;  Garcea, Elena;  Goldstein, Steve;  Goodman, Reed Charles;  Guedes, Jade Dalpoim;  Herrmann, Jason;  Hiscock, Peter;  Hommel, Peter;  Horsburgh, K. Ann;  Hritz, Carrie;  Ives, John W.;  Junno, Aripekka;  Kahn, Jennifer G.;  Kaufman, Brett;  Kearns, Catherine;  Kidder, Tristram R.;  Lanoe, Francois;  Lawrence, Dan;  Lee, Gyoung-Ah;  Levin, Maureece J.;  Lindskoug, Henrik B.;  Antonio Lopez-Saez, Jose;  Macrae, Scott;  Marchant, Rob;  Marston, John M.;  McClure, Sarah;  Mccoy, Mark D.;  Miller, Alicia Ventresca;  Morrison, Michael;  Matuzeviciute, Giedre Motuzaite;  Mueller, Johannes;  Nayak, Ayushi;  Noerwidi, Sofwan;  Peres, Tanya M.;  Peterson, Christian E.;  Proctor, Lucas;  Randall, Asa R.;  Renette, Steve;  Schug, Gwen Robbins;  Ryzewski, Krysta;  Saini, Rakesh;  Scheinsohn, Vivian;  Schmidt, Peter;  Sebillaud, Pauline;  Seitsonen, Oula;  Simpson, Ian A.;  Soltysiak, Arkadiusz;  Speakman, Robert J.;  Spengler, Robert N.;  Steffen, Martina L.;  Storozum, Michael J.;  Strickland, Keir M.;  Thompson, Jessica;  Thurston, T. L.;  Ulm, Sean;  Ustunkaya, M. Cemre;  Welker, Martin H.;  West, Catherine;  Williams, Patrick Ryan;  Wright, David K.;  Wright, Nathan;  Zahir, Muhammad;  Zerboni, Andrea;  Beaudoin, Ella;  Garcia, Santiago Munevar;  Powell, Jeremy;  Thornton, Alexa;  Kaplan, Jed O.;  Gaillard, Marie-Jose;  Goldewijk, Kees Klein;  Ellis, Erle
收藏  |  浏览/下载:57/0  |  提交时间:2019/11/27
Resonant electro-optic frequency comb 期刊论文
NATURE, 2019, 568 (7752) : 378-+
作者:  Rueda, Alfredo;  Sedlmeir, Florian;  Kumari, Madhuri;  Leuchs, Gerd;  Schwefel, Harald G. L.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Nitrogen application is required to realize wheat yield stimulation by elevated CO2 but will not remove the CO2-induced reduction in grain protein concentration 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (5) : 1868-1876
作者:  Pleijel, Hakan;  Broberg, Malin C.;  Hoegy, Petra;  Uddling, Johan
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
carbon dioxide  fertilization  nitrogen  protein  wheat  yield  
Effects of anthropogenic nitrogen discharge on dissolved inorganic nitrogen transport in global rivers 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (4) : 1493-1513
作者:  Liu, Shuang;  Xie, Zhenghui;  Zeng, Yujin;  Liu, Bin;  Li, Ruichao;  Wang, Yan;  Wang, Longhuan;  Qin, Peihua;  Jia, Binghao;  Xie, Jinbo
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
earth system model  global biogeochemical cycle  human activities  land surface model  riverine nitrogen transport  water pollution  
Organic amendment additions to rangelands: A meta-analysis of multiple ecosystem outcomes 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (3) : 1152-1170
作者:  Gravuer, Kelly;  Gennet, Sasha;  Throop, Heather L.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
arid  biodiversity  biosolids  climate change  compost  ecosystem services  grassland  runoff  savanna  soil carbon  
Climate change does not affect the seafood quality of a commonly targeted fish 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (2) : 699-707
作者:  Coleman, Melinda A.;  Butcherine, Peter;  Kelaher, Brendan P.;  Broadhurst, Matt K.;  March, Duane T.;  Provost, Euan J.;  David, Jamie;  Benkendorff, Kirsten
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
Acanthopagrus australis  acidification  climate change  fatty acid  fish  fishery  lipid  nutrition  seafood  temperature  yellowfin bream  
Effect of deforestation on access to clean drinking water 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (17) : 8249-8254
作者:  Mapulanga, Annie Mwayi;  Naito, Hisahiro
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
deforestation  water access  clean drinking water  Malawi  Africa