| DOI | 10.1038/s41586-020-2188-x
|
| A reference map of the human binary protein interactome |
| Fan, Chen1; Sukomon, Nattakan1; Flood, Emelie2; Rheinberger, Jan1,4; Allen, Toby W.2; Nimigean, Crina M.1,3
|
| 2020-03-18
|
| 发表期刊 | NATURE
 |
| ISSN | 0028-0836
|
| EISSN | 1476-4687
|
| 出版年 | 2020
|
| 卷号 | 580期号:7803页码:402-+ |
| 文章类型 | Article
|
| 语种 | 英语
|
| 国家 | USA; Canada; Spain; Belgium; Hungary; Israel; England; Italy; France |
| 英文关键词 | Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '
all-by-all'
reference interactome map of human binary protein interactions, or '
HuRI'
. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.
|
| 领域 | 地球科学
; 气候变化
; 资源环境
|
| 收录类别 | SCI-E
|
| WOS记录号 | WOS:000530151300035
|
| WOS关键词 | SCALE MAP
; BENCHMARKING
; RECEPTOR
; DISEASE
; DEFINES
; GENES
|
| WOS类目 | Multidisciplinary Sciences
|
| WOS研究方向 | Science & Technology - Other Topics
|
| 引用统计 |
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/281120
|
| 专题 | 地球科学
资源环境科学
气候变化
|
| 作者单位 | 1.Weill Cornell Med Coll, Dept Anesthesiol, New York, NY 10065 USA;
2.RMIT Univ, Sch Sci, Melbourne, Vic, Australia;
3.Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA;
4.Univ Groningen, Dept Biol Struct, Groningen Biomol Sci & Biotechnol Inst, Groningen, Netherlands
|
推荐引用方式
GB/T 7714 |
Fan, Chen,Sukomon, Nattakan,Flood, Emelie,et al. A reference map of the human binary protein interactome[J].
NATURE,2020,580(7803):402-+.
|
| APA |
Fan, Chen,Sukomon, Nattakan,Flood, Emelie,Rheinberger, Jan,Allen, Toby W.,&Nimigean, Crina M..(2020).A reference map of the human binary protein interactome.NATURE,580(7803),402-+.
|
| MLA |
Fan, Chen,et al."A reference map of the human binary protein interactome".NATURE 580.7803(2020):402-+.
|
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