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A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
Last appearance of Homo erectus at Ngandong, Java, 117,000-108,000 years ago 期刊论文
NATURE, 2020, 577 (7790) : 381-+
作者:  Haldane, Andy
收藏  |  浏览/下载:30/0  |  提交时间:2020/04/16

Homo erectus is the founding early hominin species of Island Southeast Asia, and reached Java (Indonesia) more than 1.5 million years ago(1,2). Twelve H. erectus calvaria (skull caps) and two tibiae (lower leg bones) were discovered from a bone bed located about 20 m above the Solo River at Ngandong (Central Java) between 1931 and 1933(3,4), and are of the youngest, most-advanced form of H. erectus(5-8). Despite the importance of the Ngandong fossils, the relationship between the fossils, terrace fill and ages have been heavily debated(9-14). Here, to resolve the age of the Ngandong evidence, we use Bayesian modelling of 52 radiometric age estimates to establish-to our knowledg-the first robust chronology at regional, valley and local scales. We used uranium-series dating of speleothems to constrain regional landscape evolution  luminescence, (40)argon/(39)argon (Ar-40/Ar-39) and uranium-series dating to constrain the sequence of terrace evolution  and applied uranium-series and uranium series-electron-spin resonance (US-ESR) dating to non-human fossils to directly date our re-excavation of Ngandong(5,15). We show that at least by 500 thousand years ago (ka) the Solo River was diverted into the Kendeng Hills, and that it formed the Solo terrace sequence between 316 and 31 ka and the Ngandong terrace between about 140 and 92 ka. Non-human fossils recovered during the re-excavation of Ngandong date to between 109 and 106 ka (uranium-series minimum)(16) and 134 and 118 ka (US-ESR), with modelled ages of 117 to 108 thousand years (kyr) for the H. erectus bone bed, which accumulated during flood conditions(3,17). These results negate the extreme ages that have been proposed for the site and solidify Ngandong as the last known occurrence of this long-lived species.


  
Chloride capture using a C-H hydrogen-bonding cage 期刊论文
SCIENCE, 2019, 365 (6449) : 159-+
作者:  Liu, Yun;  Zhao, Wei;  Chen, Chun-Hsing;  Flood, Amar H.
收藏  |  浏览/下载:2/0  |  提交时间:2019/11/27
Radiative forcing of methane fluxes offsets net carbon dioxide uptake for a tropical flooded forest 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (6) : 1967-1981
作者:  Dalmagro, Higo J.;  Zanella de Arruda, Paulo H.;  Vourlitis, George L.;  Lathuilliere, Michael J.;  Nogueira, Jose de S.;  Couto, Eduardo G.;  Johnson, Mark S.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/26
CH4 and CO2 fluxes  Eddy-covariance  global change  greenhouse gas balance  hyperseasonal savanna  net ecosystem carbon balance  tropical wetlands  
Anthropogenic strath terrace formation caused by reduced sediment retention 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (18) : 8734-8739
作者:  Schanz, Sarah A.;  Montgomery, David R.;  Collins, Brian D.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Anthropocene  river incision  terrace formation  Pacific Northwest  
Alternative transient states and slow plant community responses after changed flooding regimes 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (4) : 1358-1367
作者:  Sarneel, Judith M.;  Hefting, Mariet M.;  Kowalchuk, George A.;  Nilsson, Christer;  Van der Velden, Merit;  Visser, Eric J. W.;  Voesenek, Laurentius A. C. J.;  Jansson, Roland
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
alternative stable states  drought events  flood regime change  hydrological alterations  hysteresis  riparian vegetation  river restoration  species traits  
U-Pb constraints on pulsed eruption of the Deccan Traps across the end-Cretaceous mass extinction 期刊论文
SCIENCE, 2019, 363 (6429) : 862-+
作者:  Schoene, Blair;  Eddy, Michael P.;  Samperton, Kyle M.;  Keller, C. Brenhin;  Keller, Gerta;  Adatte, Thierry;  Khadri, Syed F. R.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Glacial lake outburst floods as drivers of fluvial erosion in the Himalaya 期刊论文
SCIENCE, 2018, 362 (6410) : 53-57
作者:  Cook, Kristen L.;  Andermann, Christoff;  Gimbert, Florent;  Adhikari, Basanta Raj;  Hovius, Niels
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Amazon soil charcoal: Pyrogenic carbon stock depends of ignition source distance and forest type in Roraima, Brazil 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (9) : 4122-4130
作者:  da Silva Carvalho, Lidiany C.;  Fearnside, Philip M.;  Nascimento, Marcelo T.;  Barbosa, Reinaldo I.
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
carbon sequestration  charcoal stock  global carbon cycle  pyrogenic carbon  seasonal forest  soil charcoal  
The functional response and resilience in small waterbodies along land-use and environmental gradients 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (7) : 3079-3092
作者:  Thornhill, Ian A.;  Biggs, Jeremy;  Hill, Matthew J.;  Briers, Robert;  Gledhill, David;  Wood, Paul J.;  Gee, John H. R.;  Ledger, Mark;  Hassall, Christopher
收藏  |  浏览/下载:2/0  |  提交时间:2019/04/09
ecosystem functioning  ecosystem services  functional resilience  nutrient recycling  ponds  response diversity