中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共468条，第1-10条 帮助

限定条件        
已选(0)清除 条数/页：   排序方式：
Molecular hydrogen in minerals as a clue to interpret partial derivative D variations in the mantle 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Moine, B. N.;  Bolfan-Casanova, N.;  Radu, I. B.;  Ionov, D. A.;  Costin, G.;  Korsakov, A., V;  Golovin, A., V;  Oleinikov, O. B.;  Deloule, E.;  Cottin, J. Y.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/21
Global distribution of sediment-hosted metals controlled by craton edge stability 期刊论文
NATURE GEOSCIENCE, 2020, 13 (7) : 504-+
作者:  Hoggard, Mark J.;  Czarnota, Karol;  Richards, Fred D.;  Huston, David L.;  Jaques, A. Lynton;  Ghelichkhan, Sia
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/06
Weak magnetic field changes over the Pacific due to high conductance in lowermost mantle 期刊论文
NATURE GEOSCIENCE, 2020, 13 (7) : 516-+
作者:  Dumberry, Mathieu;  More, Colin
收藏  |  浏览/下载：1/0  |  提交时间：2020/07/06
Effect of Fluid Viscosity on Earthquake Nucleation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Cornelio, C.;  Violay, M.
收藏  |  浏览/下载：20/0  |  提交时间：2020/08/18
earthquake nucleation  viscous fluids  boundary lubrication regime  
Understanding rate effects in injection-induced earthquakes 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Alghannam, Maryam;  Juanes, Ruben
收藏  |  浏览/下载：6/0  |  提交时间：2020/06/22
Feedback and Ballooning Instabilities in the Magnetosphere-Ionosphere Coupling 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Watanabe, T. -H.
收藏  |  浏览/下载：7/0  |  提交时间：2020/06/16
magnetosphere  ionosphere  Alfven waves  ballooning instability  aurora  
The Influence of Magma Mixing on the Composition of Andesite Magmas and Silicic Eruption Style 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Hodge, K. F.;  Jellinek, A. M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/16
andesite  effusive volcanism  explosive volcanism  magma mixing  rheological variations  viscosity variations  
Impacts of hydrothermal plume processes on oceanic metal cycles and transport 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 396-402
作者:  Gartman, Amy;  Findlay, Alyssa J.
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/09
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Role of Fluid Injection on Earthquake Size in Dynamic Rupture Simulations on Rough Faults 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Maurer, Jeremy;  Dunham, Eric M.;  Segall, Paul
收藏  |  浏览/下载：8/0  |  提交时间：2020/06/01
FDMAP  induced seismicity  largest magnitude  simulation  triggered seismicity  injection