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Synthesis of rare sugar isomers through site-selective epimerization 期刊论文
NATURE, 2020: 403-+
作者:  Jackson, Hartland W.;  Fischer, Jana R.;  Zanotelli, Vito R. T.;  Ali, H. Raza;  Mechera, Robert;  Soysal, Savas D.;  Moch, Holger;  Muenst, Simone;  Varga, Zsuzsanna;  Weber, Walter P.;  Bodenmiller, Bernd
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Glycans have diverse physiological functions, ranging from energy storage and structural integrity to cell signalling and the regulation of intracellular processes(1). Although biomass-derived carbohydrates (such as d-glucose, d-xylose and d-galactose) are extracted on commercial scales, and serve as renewable chemical feedstocks and building blocks(2,3), there are hundreds of distinct monosaccharides that typically cannot be isolated from their natural sources and must instead be prepared through multistep chemical or enzymatic syntheses(4,5). These '  rare'  sugars feature prominently in bioactive natural products and pharmaceuticals, including antiviral, antibacterial, anticancer and cardiac drugs(6,7). Here we report the preparation of rare sugar isomers directly from biomass carbohydrates through site-selective epimerization reactions. Mechanistic studies establish that these reactions proceed under kinetic control, through sequential steps of hydrogen-atom abstraction and hydrogen-atom donation mediated by two distinct catalysts. This synthetic strategy provides concise and potentially extensive access to this valuable class of natural compounds.


Various rare sugars that cannot be isolated from natural sources are synthesized using light-driven epimerization, a process which may find application in other synthetic scenarios.


  
Imaging magnetic polarons in the doped Fermi-Hubbard model 期刊论文
NATURE, 2019, 572 (7769) : 358-+
作者:  Koepsell, Joannis;  Vijayan, Jayadev;  Sompet, Pimonpan;  Grusdt, Fabian;  Hilker, Timon A.;  Demler, Eugene;  Salomon, Guillaume;  Bloch, Immanuel;  Gross, Christian
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Design and control of gas diffusion process in a nanoporous soft crystal 期刊论文
SCIENCE, 2019, 363 (6425) : 387-+
作者:  Gu, Cheng;  Hosono, Nobuhiko;  Zheng, Jia-Jia;  Sato, Yohei;  Kusaka, Shinpei;  Sakaki, Shigeyoshi;  Kitagawa, Susumu
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
The Sommerfeld ground-wave limit for a molecule adsorbed at a surface 期刊论文
SCIENCE, 2019, 363 (6423) : 158-161
作者:  Chen, Li;  Lau, Jascha A.;  Schwarzer, Dirk;  Meyer, Jorg;  Verma, Varun B.;  Wodtke, Alec M.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Changing available energy for extratropical cyclones and associated convection in Northern Hemisphere summer 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (10) : 4105-4110
作者:  Gertler, Charles G.;  39;Gorman, Paul A.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
climate change  available energy  extratropical cyclones  convection  
Viscous control of cellular respiration by membrane lipid composition 期刊论文
SCIENCE, 2018, 362 (6419) : 1186-+
作者:  Budin, Itay;  de Rond, Tristan;  Chen, Yan;  Chan, Leanne Jade G.;  Petzold, Christopher J.;  Keasling, Jay D.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
A hot and fast ultra-stripped supernova that likely formed a compact neutron star binary 期刊论文
SCIENCE, 2018, 362 (6411) : 201-206
作者:  De, K.;  Kasliwal, M. M.;  Ofek, E. O.;  Moriya, T. J.;  Burke, J.;  Cao, Y.;  Cenko, S. B.;  Doran, G. B.;  Duggan, G. E.;  Fender, R. P.;  Fransson, C.;  Gal-Yam, A.;  Horesh, A.;  Kulkarni, S. R.;  Laher, R. R.;  Lunnan, R.;  Manulis, I.;  Masci, F.;  Mazzali, P. A.;  Nugent, P. E.;  Perley, D. A.;  Petrushevska, T.;  Piro, A. L.;  Rumsey, C.;  Sollerman, J.;  Sullivan, M.;  Taddia, F.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Imaging of nonlocal hot-electron energy dissipation via shot noise 期刊论文
SCIENCE, 2018, 360 (6390) : 775-+
作者:  Weng, Qianchun;  Komiyama, Susumu;  Yang, Le;  An, Zhenghua;  Chen, Pingping;  Biehs, Svend-Age;  Kajihara, Yusuke;  Lu, Wei
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Electron magnetic reconnection without ion coupling in Earth's turbulent magnetosheath 期刊论文
NATURE, 2018, 557 (7704) : 202-+
作者:  Phan, T. D.;  Eastwood, J. P.;  Shay, M. A.;  Drake, J. F.;  Sonnerup, B. U. O.;  Fujimoto, M.;  Cassak, P. A.;  Oieroset, M.;  Burch, J. L.;  Torbert, R. B.;  Rager, A. C.;  Dorelli, J. C.;  Gershman, D. J.;  Pollock, C.;  Pyakurel, P. S.;  Haggerty, C. C.;  Khotyaintsev, Y.;  Lavraud, B.;  Saito, Y.;  Oka, M.;  Ergun, R. E.;  Retino, A.;  Le Contel, O.;  Argall, M. R.;  Giles, B. L.;  Moore, T. E.;  Wilder, F. D.;  Strangeway, R. J.;  Russell, C. T.;  Lindqvist, P. A.;  Magnes, W.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Geophysical potential for wind energy over the open oceans 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (43) : 11338-11343
作者:  Possner, Anna;  Caldeira, Ken
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
wind power  geophysical generation limits  offshore wind  atmosphere-turbine interactions  storm tracks