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DOI | 10.1126/science.aat7925 |
Viscous control of cellular respiration by membrane lipid composition | |
Budin, Itay1,2; de Rond, Tristan1,3,9; Chen, Yan1,4; Chan, Leanne Jade G.1,10; Petzold, Christopher J.1,4; Keasling, Jay D.1,2,5,6,7,8 | |
2018-12-07 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6419页码:1186-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark; Peoples R China |
英文摘要 | Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coil allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452506300062 |
WOS关键词 | LATERAL DIFFUSION-COEFFICIENTS ; ESCHERICHIA-COLI ; INNER-MEMBRANE ; HOMEOVISCOUS ADAPTATION ; PHOSPHOLIPID-VESICLES ; BIOLOGICAL-MEMBRANES ; NADH DEHYDROGENASE ; TERMINAL OXIDASES ; ELECTRON-TRANSFER ; KINETIC EVIDENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200243 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Joint BioEnergy Inst, 5885 Hollis St, Emeryville, CA 94608 USA; 2.Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA; 3.Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA; 4.Lawrence Berkeley Natl Lab, Biol Syst & Engn, Berkeley, CA 94720 USA; 5.Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA; 6.Univ Calif Berkeley, QB3 Inst, Berkeley, CA 94720 USA; 7.Tech Univ Denmark, Novo Nordisa Fdn Ctr Sustainabil, Lyngby, Denmark; 8.Shenzhen Inst Adv Technol, Inst Synthet Biol, Ctr Synthet Biochem, Shenzhen, Peoples R China; 9.Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA 92103 USA; 10.Calico Life Sci, San Francisco, CA USA |
推荐引用方式 GB/T 7714 | Budin, Itay,de Rond, Tristan,Chen, Yan,et al. Viscous control of cellular respiration by membrane lipid composition[J]. SCIENCE,2018,362(6419):1186-+. |
APA | Budin, Itay,de Rond, Tristan,Chen, Yan,Chan, Leanne Jade G.,Petzold, Christopher J.,&Keasling, Jay D..(2018).Viscous control of cellular respiration by membrane lipid composition.SCIENCE,362(6419),1186-+. |
MLA | Budin, Itay,et al."Viscous control of cellular respiration by membrane lipid composition".SCIENCE 362.6419(2018):1186-+. |
条目包含的文件 | 条目无相关文件。 |
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