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Controls on surface water carbonate chemistry along North American ocean margins 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Cai, Wei-Jun;  Xu, Yuan-Yuan;  Feely, Richard A.;  Wanninkhof, Rik;  Jonsson, Bror;  Alin, Simone R.;  Barbero, Leticia;  Cross, Jessica N.;  Azetsu-Scott, Kumiko;  Fassbender, Andrea J.;  Carter, Brendan R.;  Jiang, Li-Qing;  Pepin, Pierre;  Chen, Baoshan;  Hussain, Najid;  Reimer, Janet J.;  Xue, Liang;  Salisbury, Joseph E.;  Martin Hernandez-Ayon, Jose;  Langdon, Chris;  Li, Qian;  Sutton, Adrienne J.;  Chen, Chen-Tung A.;  Gledhill, Dwight K.
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/09
Deposition, recycling, and archival of nitrate stable isotopes between the air-snow interface: comparison between Dronning Maud Land and Dome C, Antarctica 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5861-5885
作者:  Winton, V. Holly L.;  Ming, Alison;  Caillon, Nicolas;  Hauge, Lisa;  Jones, Anna;  Savarino, Joel;  Yang, Xin;  Frey, Markus M.
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/20
Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5197-5210
作者:  Gao, Dong;  Pollitt, Krystal J. Godri;  Mulholland, James A.;  Russell, Armistead G.;  Weber, Rodney J.
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).


  
Assessing the sensitivity of land-atmosphere coupling strength to boundary and surface layer parameters in the WRF model over Amazon 期刊论文
ATMOSPHERIC RESEARCH, 2020, 234
作者:  Wang, Chen;  Qian, Yun;  Duan, Qingyun;  Huang, Maoyi;  Berg, Larry K.;  Shin, Hyeyum H.;  Feng, Zhe;  Yang, Ben;  Quan, Jiping;  Hong, Songyou;  Yan, Junhua
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
L-A coupling strength  Amazon region  WRF model  Model uncertainties  Parameter sensitivity analysis  
The Role of Wind Speed and Wind Shear for Banner Cloud Formation 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2020, 77 (4) : 1199-1212
作者:  Wirth, Volkmar;  Bubel, Pascal;  Eichhorn, Joachim;  Schoemer, Elmar;  Kremer, Tobias;  Erbes, Rainer;  Schappert, Sebastian;  Prestel, Isabelle
收藏  |  浏览/下载:4/0  |  提交时间:2020/07/02
Atmosphere  Orographic effects  Vertical motion  Boundary layer  Large eddy simulations  Mountain meteorology  
Ozone-vegetation feedback through dry deposition and isoprene emissions in a global chemistry-carbon-climate model 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 3841-3857
作者:  Gong, Cheng;  Lei, Yadong;  Ma, Yimian;  Yue, Xu;  Liao, Hong
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Surface temperature response to regional black carbon emissions: do location and magnitude matter? 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 3079-3089
作者:  Sand, Maria;  Berntsen, Terje K.;  Ekman, Annica M. L.;  Hansson, Hans-Christen;  Lewinschal, Anna
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/02
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities 期刊论文
NATURE, 2020
作者:  Yang, Jianfeng;  Faccenda, Manuele
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/03

Cancer genomics studies have identified thousands of putative cancer driver genes(1). Development of high-throughput and accurate models to define the functions of these genes is a major challenge. Here we devised a scalable cancer-spheroid model and performed genome-wide CRISPR screens in 2D monolayers and 3D lung-cancer spheroids. CRISPR phenotypes in 3D more accurately recapitulated those of in vivo tumours, and genes with differential sensitivities between 2D and 3D conditions were highly enriched for genes that are mutated in lung cancers. These analyses also revealed drivers that are essential for cancer growth in 3D and in vivo, but not in 2D. Notably, we found that carboxypeptidase D is responsible for removal of a C-terminal RKRR motif(2) from the alpha-chain of the insulin-like growth factor 1 receptor that is critical for receptor activity. Carboxypeptidase D expression correlates with patient outcomes in patients with lung cancer, and loss of carboxypeptidase D reduced tumour growth. Our results reveal key differences between 2D and 3D cancer models, and establish a generalizable strategy for performing CRISPR screens in spheroids to reveal cancer vulnerabilities.


CRISPR screens in a 3D spheroid cancer model system more accurately recapitulate cancer phenotypes than existing 2D models and were used to identify carboxypeptidase D, acting via the IGF1R, as a 3D-specific driver of cancer growth.


  
A Case Study of the Physical Processes Associated with the Atmospheric River Initial-Condition Sensitivity from an Adjoint Model 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2020, 77 (2) : 691-709
作者:  Demirdjian, Reuben;  Doyle, James D.;  Reynolds, Carolyn A.;  Norris, Joel R.;  Michaelis, Allison C.;  Ralph, F. Martin
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/02
Extratropical cyclones  Lagrangian circulation  transport  Mesoscale processes  Topographic effects  Fronts  Jets