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Experimental evidence of dispersal of invasive cyprinid inside waterfowl 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (27) : 15397-15399
作者:  Lovas-Kiss, Adam;  Vincze, Orsolya;  Loki, Viktor;  Paller-Kapusi, Felicia;  Halasi-Kovacs, Bela;  Kovacs, Gyula;  Green, Andy J.;  Lukacs, Balazs Andras
收藏  |  浏览/下载：6/0  |  提交时间：2020/06/29
long-distance dispersal  freshwater  fish distribution  invasion  endozoochory  
Climate impact on fluvial-lake system evolution, Eocene Green River Formation, Uinta Basin, Utah, USA 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (3-4) : 562-587
作者:  Birgenheier, L. P.;  Vanden Berg, M. D.;  Plink-Bjorklund, P.;  Gall, R. D.;  Rosencrans, E.;  Rosenberg, M. J.;  Toms, L. C.;  Morris, J.
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.


  
Grand challenges in the science of wind energy 期刊论文
SCIENCE, 2019, 366 (6464) : 443-+
作者:  Veers, Paul;  Dykes, Katherine;  Lantz, Eric;  Barth, Stephan;  Bottasso, Carlo L.;  Carlson, Ola;  Clifton, Andrew;  Green, Johney;  Green, Peter;  Holttinen, Hannele;  Laird, Daniel;  Lehtomaki, Ville;  Lundquist, Julie K.;  Manwell, James;  Marquis, Melinda;  Meneveau, Charles;  Moriarty, Patrick;  Munduate, Xabier;  Muskulus, Michael;  Naughton, Jonathan;  Pao, Lucy;  Paquette, Joshua;  Peinke, Joachim;  Robertson, Amy;  Sanz Rodrigo, Javier;  Sempreviva, Anna Maria;  Smith, J. Charles;  Tuohy, Aidan;  Wiser, Ryan
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Seismic geomorphology and sedimentology of a fluvial-dominated delta: Implications for the Neogene reservoirs, offshore Bohai Bay Basin, China 期刊论文
AAPG BULLETIN, 2019, 103 (10) : 2399-2420
作者:  Xu, Shang;  Hao, Fang;  Xu, Changgui;  Zou, Huayao;  Gao, Baishui
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
Thyroid hormone signaling specifies cone subtypes in human retinal organoids 期刊论文
SCIENCE, 2018, 362 (6411) : 200-+
作者:  Eldred, Kiara C.;  Hadyniak, Sarah E.;  Hussey, Katarzyna A.;  Brenerman, Boris;  Zhang, Ping-Wu;  Chamling, Xitiz;  Sluch, Valentin M.;  Welsbie, Derek S.;  Hattar, Samer;  Taylor, James;  Wahlin, Karl;  Zack, Donald J.;  Johnston, Robert J., Jr.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Shortwave infrared (1.0-2.5 mm) hyperspectral imaging of the Athabasca West Grand Rapids Formation oil sands 期刊论文
AAPG BULLETIN, 2018, 102 (9) : 1671-1683
作者:  Speta, Michelle;  Rivard, Benoit;  Feng, Jilu
收藏  |  浏览/下载：0/0  |  提交时间：2019/04/09
China's response to a national land-system sustainability emergency 期刊论文
NATURE, 2018, 559 (7713) : 193-204
作者:  Bryan, Brett A.;  Gao, Lei;  Ye, Yanqiong;  Sun, Xiufeng;  Connor, Jeffery D.;  Crossman, Neville D.;  Stafford-Smith, Mark;  Wu, Jianguo;  He, Chunyang;  Yu, Deyong;  Liu, Zhifeng;  Li, Ang;  Huang, Qingxu;  Ren, Hai;  Deng, Xiangzheng;  Zheng, Hua;  Niu, Jianming;  Han, Guodong;  Hou, Xiangyang
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
The development and extent of photic-zone euxinia concomitant with Woodford Shale deposition 期刊论文
AAPG BULLETIN, 2018, 102 (6) : 959-986
作者:  Connock, Gregory T.;  Nguyen, Thanh X.;  Philp, R. Paul
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
CCN activity and organic hygroscopicity of aerosols downwind of an urban region in central Amazonia: seasonal and diel variations and impact of anthropogenic emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (19)
作者:  Thalman, Ryan;  de Sa, Suzane S.;  Palm, Brett B.;  Barbosa, Henrique M. J.;  Poehlker, Mira L.;  Alexander, M. Lizabeth;  Brito, Joel;  Carbone, Samara;  Castillo, Paulo;  Day, Douglas A.;  Kuang, Chongai;  Manzi, Antonio;  Ng, Nga Lee;  Sedlacek, Arthur J., III;  Souza, Rodrigo;  Springston, Stephen;  Watson, Thomas;  Poehlker, Christopher;  Poeschl, Ulrich;  Andreae, Meinrat O.;  Artaxo, Paulo;  Jimenez, Jose L.;  Martin, Scot T.;  Wang, Jian
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09