Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau6348 |
Thyroid hormone signaling specifies cone subtypes in human retinal organoids | |
Eldred, Kiara C.1; Hadyniak, Sarah E.1; Hussey, Katarzyna A.1; Brenerman, Boris1; Zhang, Ping-Wu2; Chamling, Xitiz2; Sluch, Valentin M.2; Welsbie, Derek S.3; Hattar, Samer4; Taylor, James1,5; Wahlin, Karl3; Zack, Donald J.2,6,7,8; Johnston, Robert J., Jr.1 | |
2018-10-12 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6411页码:200-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The mechanisms underlying specification of neuronal subtypes within the human nervous system are largely unknown. The blue (S), green (M), and red (L) cones of the retina enable high-acuity daytime and color vision. To determine the mechanism that controls S versus L/M fates, we studied the differentiation of human retinal organoids. Organoids and retinas have similar distributions, expression profiles, and morphologies of cone subtypes. S cones are specified first, followed by L/M cones, and thyroid hormone signaling controls this temporal switch. Dynamic expression of thyroid hormone-degrading and -activating proteins within the retina ensures low signaling early to specify S cones and high signaling late to produce L/M cones. This work establishes organoids as a model for determining mechanisms of human development with promising utility for therapeutics and vision repair. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447337200049 |
WOS关键词 | MUTUALLY EXCLUSIVE EXPRESSION ; VISUAL PIGMENT GENES ; LOCUS-CONTROL REGION ; OPSIN EXPRESSION ; HUMAN RED ; MOLECULAR-GENETICS ; TYPE-3 DEIODINASE ; HOMEOBOX GENE ; MOUSE RETINA ; COLOR-VISION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199808 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ, Dept Biol, 3400 N Charles St, Baltimore, MD 21218 USA; 2.Johns Hopkins Univ, Wilmer Eye Inst, Sch Med, Baltimore, MD 21287 USA; 3.Univ Calif San Diego, Shiley Eye Inst, La Jolla, CA 92093 USA; 4.NIMH, NIH, Bethesda, MD 20892 USA; 5.Johns Hopkins Univ, Dept Comp Sci, 3400 N Charles St, Baltimore, MD 21218 USA; 6.Johns Hopkins Univ, Dept Mol Biol & Genet, Sch Med, Baltimore, MD 21287 USA; 7.Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21287 USA; 8.Johns Hopkins Univ, Sch Med, Inst Genet Med, Baltimore, MD 21287 USA |
推荐引用方式 GB/T 7714 | Eldred, Kiara C.,Hadyniak, Sarah E.,Hussey, Katarzyna A.,et al. Thyroid hormone signaling specifies cone subtypes in human retinal organoids[J]. SCIENCE,2018,362(6411):200-+. |
APA | Eldred, Kiara C..,Hadyniak, Sarah E..,Hussey, Katarzyna A..,Brenerman, Boris.,Zhang, Ping-Wu.,...&Johnston, Robert J., Jr..(2018).Thyroid hormone signaling specifies cone subtypes in human retinal organoids.SCIENCE,362(6411),200-+. |
MLA | Eldred, Kiara C.,et al."Thyroid hormone signaling specifies cone subtypes in human retinal organoids".SCIENCE 362.6411(2018):200-+. |
条目包含的文件 | 条目无相关文件。 |
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