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Indigenous mental health in a changing climate: a systematic scoping review of the global literature 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (5)
作者:  Middleton, Jacqueline;  Cunsolo, Ashlee;  Jones-Bitton, Andria;  Wright, Carlee J.;  Harper, Sherilee L.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/02
Indigenous health  climate change  mental health  weather  seasonality  intangible loss and damage  scoping review methodology  
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.


  
Impact of Tropical Cyclone Landfall Angle on Storm Surge Along the Mid-Atlantic Bight 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (4)
作者:  Ramos-Valle, Alexandra N.;  Curchitser, Enrique N.;  Bruyere, Cindy L.
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/02
Adoption of improved biomass stoves in Kenya: a transect-based approach in Kiambu and Muranga counties 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (2)
作者:  Karanja, Alice;  Gasparatos, Alexandros
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
stove adoption  clean stoves  improved biomass stoves  gender  geographical location  sub-Saharan Africa  
Ensemble Sensitivity Analysis of Heavy Rainfall Associated With Three MCSs Coexisting Over Southern China 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (2)
作者:  Shen, Yian;  Du, Yu;  Chen, Guixing
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Global-scale remote sensing of mine areas and analysis of factors explaining their extent 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 60
作者:  Werner, Tim T.;  Mudd, Gavin M.;  Schipper, Aafke M.;  Huijbregt, Mark A. J.;  Taneja, Lakshay;  Northey, Stephen A.
收藏  |  浏览/下载：7/0  |  提交时间：2020/07/02
Mining  Remote sensing  GIS  Land use change  Impact assessment