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Deciphering the extreme rainfall scenario over Indian landmass using satellite observations, reanalysis and model forecast: Case studies 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Saha, Upal;  Singh, Tarkeshwar;  Sharma, Priti;  Das Gupta, M.;  Prasad, V. S.
收藏  |  浏览/下载：17/0  |  提交时间：2020/08/18
Extreme rainfall  Monsoon  Instability  Global forecast system  Unified Model  
Supercooled drizzle development in response to semi-coherent vertical velocity fluctuations within an orographic-layer cloud 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (8) : 5035-5054
作者:  Majewski, Adam;  French, Jeffrey R.
收藏  |  浏览/下载：7/0  |  提交时间：2020/05/13
Surface temperature response to regional black carbon emissions: do location and magnitude matter? 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 3079-3089
作者:  Sand, Maria;  Berntsen, Terje K.;  Ekman, Annica M. L.;  Hansson, Hans-Christen;  Lewinschal, Anna
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/02
Ambient air quality in the Kathmandu Valley, Nepal, during the pre-monsoon: concentrations and sources of particulate matter and trace gases 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 2927-2951
作者:  Islam, Md Robiul;  Jayarathne, Thilina;  Simpson, Isobel J.;  Werden, Benjamin;  Maben, John;  Gilbert, Ashley;  Praveen, Puppala S.;  Adhikari, Sagar;  Panday, Arnico K.;  Rupakheti, Maheswar;  Blake, Donald R.;  Yokelson, Robert J.;  DeCarlo, Peter F.;  Keene, William C.;  Stone, Elizabeth A.
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/02
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.