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A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
Demonstration of cooling by the Muon Ionization Cooling Experiment 期刊论文
NATURE, 2020, 578 (7793) : 53-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such '  tertiary'  beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton-antilepton collisions at extremely high energies and provide well characterized neutrino beams(1-6). Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness(7,8). Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect(9-11). The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced wfootprint(6).


  
Resonant electro-optic frequency comb 期刊论文
NATURE, 2019, 568 (7752) : 378-+
作者:  Rueda, Alfredo;  Sedlmeir, Florian;  Kumari, Madhuri;  Leuchs, Gerd;  Schwefel, Harald G. L.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
The true tempo of evolutionary radiation and decline revealed on the Hawaiian archipelago 期刊论文
NATURE, 2017, 543 (7647) : 710-+
作者:  Lim, Jun Y.;  Marshall, Charles R.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
The genome of Chenopodium quinoa 期刊论文
NATURE, 2017, 542 (7641) : 307-+
作者:  Jarvis, David E.;  Ho, Yung Shwen;  Lightfoot, Damien J.;  Schmockel, Sandra M.;  Li, Bo;  Borm, Theo J. A.;  Ohyanagi, Hajime;  Mineta, Katsuhiko;  Michell, Craig T.;  Saber, Noha;  Kharbatia, Najeh M.;  Rupper, Ryan R.;  Sharp, Aaron R.;  Dally, Nadine;  Boughton, Berin A.;  Woo, Yong H.;  Gao, Ge;  Schijlen, Elio G. W. M.;  Guo, Xiujie;  Momin, Afaque A.;  Negrao, Sonia;  Al-Babili, Salim;  Gehring, Christoph;  Roessner, Ute;  Jung, Christian;  Murphy, Kevin;  Arold, Stefan T.;  Gojobori, Takashi;  van der Linden, C. Gerard;  van Loo, Eibertus N.;  Jellen, Eric N.;  Maughan, Peter J.;  Tester, Mark
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09