Ecological drivers of intragenomic conflict resolution

GSTDTAP

项目编号	NE/R008825/1
	Ecological drivers of intragenomic conflict resolution
	Michael Alan Brockhurst
主持机构	University of Sheffield
项目开始年	2018
	2018-02-01
项目结束日期	2021-01-31
资助机构	UK-NERC
项目类别	Research Grant
项目经费	487227(GBP)
国家	英国
语种	英语
英文摘要	The classical view of evolution is as a process of gradual accumulation of small changes by mutations passed on to descendants. However, genome sequencing has revealed that in bacteria genes are frequently exchanged between cells and species by a process called horizontal gene transfer, allowing evolution to make big, fast jumps. Genes often pass from one bacterial cell to another on circular pieces of DNA called plasmids. However, acquiring a plasmid can be costly to a bacterial cell because plasmids use energy and introduce new genes that disrupt the normal working of the bacterium. In evolutionary theory these costs are called intragenomic conflicts because what is good for the plasmid is bad for the bacterial chromosome, and vice versa. We have recently shown that evolution can resolve these conflicts by a process of 'compensatory evolution', whereby either the bacterial chromosome or the plasmid gains mutations that lessen the cost of carrying the plasmid. By increasing plasmid survival, compensatory evolution is likely to increase the chance of new genes jumping onto plasmids from bacterial chromosomes, allowing these to be shared with other species in the community. In this proposal we will discover how the ecology of microbial communities and the environments they live in shape the processes of compensatory evolution, and whether compensatory evolution itself speeds up the sharing of genes between species.
来源学科分类	Natural Environment Research
文献类型	项目
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/87028
专题	环境与发展全球科技态势
推荐引用方式 GB/T 7714	Michael Alan Brockhurst.Ecological drivers of intragenomic conflict resolution.2018.