GSTDTAP  > 资源环境科学
DOI10.1073/pnas.2014929118
Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs
Joanna L. Kelley; Michael Tobler; Daniel Beck; Ingrid Sadler-Riggleman; Corey R. Quackenbush; Lenin Arias Rodriguez; Michael K. Skinner
2021-06-29
Source PublicationProceedings of the National Academy of Sciences
Year Published2021
Abstract in English

Environmental factors can promote phenotypic variation through alterations in the epigenome and facilitate adaptation of an organism to the environment. Although hydrogen sulfide is toxic to most organisms, the fish Poecilia mexicana has adapted to survive in environments with high levels that exceed toxicity thresholds by orders of magnitude. Epigenetic changes in response to this environmental stressor were examined by assessing DNA methylation alterations in red blood cells, which are nucleated in fish. Males and females were sampled from sulfidic and nonsulfidic natural environments; individuals were also propagated for two generations in a nonsulfidic laboratory environment. We compared epimutations between the sexes as well as field and laboratory populations. For both the wild-caught (F0) and the laboratory-reared (F2) fish, comparing the sulfidic and nonsulfidic populations revealed evidence for significant differential DNA methylation regions (DMRs). More importantly, there was over 80% overlap in DMRs across generations, suggesting that the DMRs have stable generational inheritance in the absence of the sulfidic environment. This is an example of epigenetic generational stability after the removal of an environmental stressor. The DMR-associated genes were related to sulfur toxicity and metabolic processes. These findings suggest that adaptation of P. mexicana to sulfidic environments in southern Mexico may, in part, be promoted through epigenetic DNA methylation alterations that become stable and are inherited by subsequent generations independent of the environment.

Field资源环境
URL查看原文
Citation statistics
Document Type期刊论文
Identifierhttp://119.78.100.173/C666/handle/2XK7JSWQ/330729
Collection资源环境科学
Recommended Citation
GB/T 7714
Joanna L. Kelley,Michael Tobler,Daniel Beck,等. Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs[J]. Proceedings of the National Academy of Sciences,2021.
APA Joanna L. Kelley.,Michael Tobler.,Daniel Beck.,Ingrid Sadler-Riggleman.,Corey R. Quackenbush.,...&Michael K. Skinner.(2021).Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs.Proceedings of the National Academy of Sciences.
MLA Joanna L. Kelley,et al."Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs".Proceedings of the National Academy of Sciences (2021).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Joanna L. Kelley]'s Articles
[Michael Tobler]'s Articles
[Daniel Beck]'s Articles
Baidu academic
Similar articles in Baidu academic
[Joanna L. Kelley]'s Articles
[Michael Tobler]'s Articles
[Daniel Beck]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Joanna L. Kelley]'s Articles
[Michael Tobler]'s Articles
[Daniel Beck]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.