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DOI10.1073/pnas.2014929118
Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs
Joanna L. Kelley; Michael Tobler; Daniel Beck; Ingrid Sadler-Riggleman; Corey R. Quackenbush; Lenin Arias Rodriguez; Michael K. Skinner
2021-06-29
发表期刊Proceedings of the National Academy of Sciences
出版年2021
英文摘要

Environmental factors can promote phenotypic variation through alterations in the epigenome and facilitate adaptation of an organism to the environment. Although hydrogen sulfide is toxic to most organisms, the fish Poecilia mexicana has adapted to survive in environments with high levels that exceed toxicity thresholds by orders of magnitude. Epigenetic changes in response to this environmental stressor were examined by assessing DNA methylation alterations in red blood cells, which are nucleated in fish. Males and females were sampled from sulfidic and nonsulfidic natural environments; individuals were also propagated for two generations in a nonsulfidic laboratory environment. We compared epimutations between the sexes as well as field and laboratory populations. For both the wild-caught (F0) and the laboratory-reared (F2) fish, comparing the sulfidic and nonsulfidic populations revealed evidence for significant differential DNA methylation regions (DMRs). More importantly, there was over 80% overlap in DMRs across generations, suggesting that the DMRs have stable generational inheritance in the absence of the sulfidic environment. This is an example of epigenetic generational stability after the removal of an environmental stressor. The DMR-associated genes were related to sulfur toxicity and metabolic processes. These findings suggest that adaptation of P. mexicana to sulfidic environments in southern Mexico may, in part, be promoted through epigenetic DNA methylation alterations that become stable and are inherited by subsequent generations independent of the environment.

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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/330729
专题资源环境科学
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Joanna L. Kelley,Michael Tobler,Daniel Beck,等. Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs[J]. Proceedings of the National Academy of Sciences,2021.
APA Joanna L. Kelley.,Michael Tobler.,Daniel Beck.,Ingrid Sadler-Riggleman.,Corey R. Quackenbush.,...&Michael K. Skinner.(2021).Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs.Proceedings of the National Academy of Sciences.
MLA Joanna L. Kelley,et al."Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs".Proceedings of the National Academy of Sciences (2021).
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