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DOI | 10.1289/EHP8054 |
Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays | |
Anna S. Young; Thomas Zoeller; Russ Hauser; Tamarra James-Todd; Brent A. Coull; Peter A. Behnisch; Abraham Brouwer; Hongkai Zhu; Kurunthachalam Kannan; Joseph G. Allen | |
2021-04-14 | |
发表期刊 | Environmental Health Perspectives
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出版年 | 2021 |
英文摘要 | AbstractBackground:Per- and polyfluoroalkyl substances (PFAS), organophosphate esters (OPEs), and polybrominated diphenyl ethers (PBDEs) are hormone-disrupting chemicals that migrate from building materials into air and dust. Objectives:We aimed to quantify the hormonal activities of 46 dust samples and identify chemicals driving the observed activities. Methods:We evaluated associations between hormonal activities of extracted dust in five cell-based luciferase reporter assays and dust concentrations of 42 measured PFAS, OPEs, and PBDEs, transformed as either raw or potency-weighted concentrations based on Tox21 high-throughput screening data. Results:All dust samples were hormonally active, showing antagonistic activity toward peroxisome proliferator-activated receptor () (100%; 46 of 46 samples), thyroid hormone receptor () (89%; 41 samples), and androgen receptor (AR) (87%; 40 samples); agonist activity on estrogen receptor () (96%; 44 samples); and binding competition with thyroxine () on serum transporter transthyretin (TTR) (98%; 45 samples). Effects were observed with as little as of extracted dust. In regression models for each chemical class, interquartile range increases in potency-weighted or unknown-potency chemical concentrations were associated with higher hormonal activities of dust extracts (potency-weighted: , , ; , , ; , , ; , , ; unknown-potency: , , ; , , ), adjusted for chemicals with active, inactive, and unknown Tox21 designations. Discussion:All indoor dust samples exhibited hormonal activities, which were associated with PFAS, PBDE, and OPE levels. Reporter gene cell-based assays are relatively inexpensive, health-relevant evaluations of toxic loads of chemical mixtures that building occupants are exposed to. https://doi.org/10.1289/EHP8054 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/322753 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Anna S. Young,Thomas Zoeller,Russ Hauser,et al. Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays[J]. Environmental Health Perspectives,2021. |
APA | Anna S. Young.,Thomas Zoeller.,Russ Hauser.,Tamarra James-Todd.,Brent A. Coull.,...&Joseph G. Allen.(2021).Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays.Environmental Health Perspectives. |
MLA | Anna S. Young,et al."Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays".Environmental Health Perspectives (2021). |
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