Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast

doi:10.1126/science.aba0542

GSTDTAP > 气候变化

DOI	10.1126/science.aba0542
	Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast
	James Boocock; Meru J. Sadhu; Arun Durvasula; Joshua S. Bloom; Leonid Kruglyak
	2021-01-22
发表期刊	Science
出版年	2021
英文摘要	Some organisms can switch metabolic pathways depending on their environment. One such example is yeast, which can transition between the sugars glucose and galactose as carbon sources. Boocock et al. show that this ability has undergone selection, resulting in the maintenance of two incompatible metabolic pathways in a select set of yeast strains within a single species. A phylogenetic analysis supports that these different pathways are mediated by three genes that differ between strains within and among yeast species and likely have been maintained over 10 million to 20 million years. Science , this issue p. [415][1] Metabolic pathways differ across species but are expected to be similar within a species. We discovered two functional, incompatible versions of the galactose pathway in Saccharomyces cerevisiae . We identified a three-locus genetic interaction for growth in galactose, and used precisely engineered alleles to show that it arises from variation in the galactose utilization genes GAL2 , GAL1/10/7 , and phosphoglucomutase ( PGM1 ), and that the reference allele of PGM1 is incompatible with the alternative alleles of the other genes. Multiloci balancing selection has maintained the two incompatible versions of the pathway for millions of years. Strains with alternative alleles are found primarily in galactose-rich dairy environments, and they grow faster in galactose but slower in glucose, revealing a trade-off on which balancing selection may have acted. [1]: /lookup/doi/10.1126/science.aba0542
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/312371
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	James Boocock,Meru J. Sadhu,Arun Durvasula,et al. Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast[J]. Science,2021.
APA	James Boocock,Meru J. Sadhu,Arun Durvasula,Joshua S. Bloom,&Leonid Kruglyak.(2021).Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast.Science.
MLA	James Boocock,et al."Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast".Science (2021).