A chimeric gene paternally instructs female sex determination in the haplodiploid wasp <em>Nasonia</em>

doi:10.1126/science.abb8949

GSTDTAP > 气候变化

DOI	10.1126/science.abb8949
	A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia
	Yuan Zou; Elzemiek Geuverink; Leo W. Beukeboom; Eveline C. Verhulst; Louis van de Zande
	2020-11-27
发表期刊	Science
出版年	2020
英文摘要	Not all animals have specialized sex chromosomes to determine their sex. In hymenopteran insects, for example, unfertilized eggs become males and fertilized eggs become females. Prior work showed that the paternal genome provides instruction for female development. Zou et al. identified a sex determination instructor gene, wasp overruler of masculinization , with parent-of-origin effect, in the parasitoid Nasonia vitripennis . It is only transcribed from the paternally provided genome in fertilized eggs to initiate female development. This discovery provides insights into the molecular basis and evolution of sex determination. Science , this issue p. [1115][1] Various primary signals direct insect sex determination. In hymenopteran insects, the presence of a paternal genome is needed to initiate female development. When absent, uniparental haploid males develop. We molecularly and functionally identified the instructor sex-determination gene, wasp overruler of masculinization ( wom ), of the haplodiploid wasp Nasonia vitripennis . This gene contains a P53-like domain coding region and arose by gene duplication and genomic rearrangements. Maternal silencing of wom results in male development of haploid embryos. Upon fertilization, early zygotic transcription from the paternal wom allele is initiated, followed by a timely zygotic expression of transformer ( tra ), leading to female development. Wom is an instructor gene with a parent-of-origin effect in sex determination. [1]: /lookup/doi/10.1126/science.abb8949
领域	气候变化 ; 资源环境
URL	查看原文
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/304893
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Yuan Zou,Elzemiek Geuverink,Leo W. Beukeboom,et al. A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia[J]. Science,2020.
APA	Yuan Zou,Elzemiek Geuverink,Leo W. Beukeboom,Eveline C. Verhulst,&Louis van de Zande.(2020).A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia.Science.
MLA	Yuan Zou,et al."A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia".Science (2020).