Microbiota-modulated CART<sup>+</sup> enteric neurons autonomously regulate blood glucose

doi:10.1126/science.abd6176

GSTDTAP > 气候变化

DOI	10.1126/science.abd6176
	Microbiota-modulated CART⁺ enteric neurons autonomously regulate blood glucose
	Paul A. Muller; Fanny Matheis; Marc Schneeberger; Zachary Kerner; Veronica Jové; Daniel Mucida
	2020-10-16
发表期刊	Science
出版年	2020
英文摘要	The gut is a stretchy, glandular, and highly innervated tube packed at its distal end with microorganisms. Disruption of the microbial community can lead to metabolic disorders such as obesity and diabetes. Muller et al. investigated how the microbiota interacts with the enteric nervous system to induce a metabolic outcome. A population of autonomous enteric neurons called CART+ neurons are enriched in the ileum and colon, where most of the microbiota resides. Stimulation or ablation of the CART+ neurons alters blood glucose levels, insulin, and feeding behavior. Furthermore, by manipulating the microbiota, the density of enteric neurons responds plastically in an inducible and reversible manner. Science , this issue p. [314][1] The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more responsive to microbial colonization than duodenal neurons. Specifically, a microbially responsive subset of viscerofugal CART+ neurons, enriched in the ileum and colon, modulated feeding and glucose metabolism. These CART+ neurons send axons to the prevertebral ganglia and are polysynaptically connected to the liver and pancreas. Microbiota depletion led to NLRP6- and caspase 11–dependent loss of CART+ neurons and impaired glucose regulation. Hence, iEAN subsets appear to be capable of regulating blood glucose levels independently from the central nervous system. [1]: /lookup/doi/10.1126/science.abd6176
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/299339
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Paul A. Muller,Fanny Matheis,Marc Schneeberger,et al. Microbiota-modulated CART⁺ enteric neurons autonomously regulate blood glucose[J]. Science,2020.
APA	Paul A. Muller,Fanny Matheis,Marc Schneeberger,Zachary Kerner,Veronica Jové,&Daniel Mucida.(2020).Microbiota-modulated CART⁺ enteric neurons autonomously regulate blood glucose.Science.
MLA	Paul A. Muller,et al."Microbiota-modulated CART⁺ enteric neurons autonomously regulate blood glucose".Science (2020).