Beyond aggregation: Pathological phase transitions in neurodegenerative disease

doi:10.1126/science.abb8032

GSTDTAP > 气候变化

DOI	10.1126/science.abb8032
	Beyond aggregation: Pathological phase transitions in neurodegenerative disease
	Cécile Mathieu; Rohit V. Pappu; J. Paul Taylor
	2020-10-02
发表期刊	Science
出版年	2020
英文摘要	Over the past decade, phase transitions have emerged as a fundamental mechanism of cellular organization. In parallel, a wealth of evidence has accrued indicating that aberrations in phase transitions are early events in the pathogenesis of several neurodegenerative diseases. We review the key evidence of defects at multiple levels, from phase transition of individual proteins to the dynamic behavior of complex, multicomponent condensates in neurodegeneration. We also highlight two concepts, dynamical arrest and heterotypic buffering, that are key to understanding how pathological phase transitions relate to pleiotropic defects in cellular functions and the accrual of proteinaceous deposits at end-stage disease. These insights not only illuminate disease etiology but also are likely to guide the development of therapeutic interventions to restore homeostasis.
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298021
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Cécile Mathieu,Rohit V. Pappu,J. Paul Taylor. Beyond aggregation: Pathological phase transitions in neurodegenerative disease[J]. Science,2020.
APA	Cécile Mathieu,Rohit V. Pappu,&J. Paul Taylor.(2020).Beyond aggregation: Pathological phase transitions in neurodegenerative disease.Science.
MLA	Cécile Mathieu,et al."Beyond aggregation: Pathological phase transitions in neurodegenerative disease".Science (2020).