Mitochondrial dynamics in postmitotic cells regulate neurogenesis

doi:10.1126/science.aba9760

GSTDTAP > 气候变化

DOI	10.1126/science.aba9760
	Mitochondrial dynamics in postmitotic cells regulate neurogenesis
	Ryohei Iwata; Pierre Casimir; Pierre Vanderhaeghen
	2020-08-14
发表期刊	Science
出版年	2020
英文摘要	Radial glia cells, the stem cells of early brain development, can generate more of themselves or generate differentiating neurons. Iwata et al. now show that these fate decisions involve the mitochondria. Cells that have fragmented mitochondria shortly after mitosis are more likely to become neurons, whereas cells that are undergoing mitochondrial fusion are likely to continue being stem cells. Science , this issue p. [858][1] The conversion of neural stem cells into neurons is associated with the remodeling of organelles, but whether and how this is causally linked to fate change is poorly understood. We examined and manipulated mitochondrial dynamics during mouse and human cortical neurogenesis. We reveal that shortly after cortical stem cells have divided, daughter cells destined to self-renew undergo mitochondrial fusion, whereas those that retain high levels of mitochondria fission become neurons. Increased mitochondria fission promotes neuronal fate, whereas induction of mitochondria fusion after mitosis redirects daughter cells toward self-renewal. This occurs during a restricted time window that is doubled in human cells, in line with their increased self-renewal capacity. Our data reveal a postmitotic period of fate plasticity in which mitochondrial dynamics are linked with cell fate. [1]: /lookup/doi/10.1126/science.aba9760
领域	气候变化 ; 资源环境
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/288096
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Ryohei Iwata,Pierre Casimir,Pierre Vanderhaeghen. Mitochondrial dynamics in postmitotic cells regulate neurogenesis[J]. Science,2020.
APA	Ryohei Iwata,Pierre Casimir,&Pierre Vanderhaeghen.(2020).Mitochondrial dynamics in postmitotic cells regulate neurogenesis.Science.
MLA	Ryohei Iwata,et al."Mitochondrial dynamics in postmitotic cells regulate neurogenesis".Science (2020).