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DOI | 10.1126/science.aba9760 |
Mitochondrial dynamics in postmitotic cells regulate neurogenesis | |
Ryohei Iwata; Pierre Casimir; Pierre Vanderhaeghen | |
2020-08-14 | |
发表期刊 | Science
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出版年 | 2020 |
英文摘要 | Radial glia cells, the stem cells of early brain development, can generate more of themselves or generate differentiating neurons. Iwata et al. now show that these fate decisions involve the mitochondria. Cells that have fragmented mitochondria shortly after mitosis are more likely to become neurons, whereas cells that are undergoing mitochondrial fusion are likely to continue being stem cells. Science , this issue p. [858][1] The conversion of neural stem cells into neurons is associated with the remodeling of organelles, but whether and how this is causally linked to fate change is poorly understood. We examined and manipulated mitochondrial dynamics during mouse and human cortical neurogenesis. We reveal that shortly after cortical stem cells have divided, daughter cells destined to self-renew undergo mitochondrial fusion, whereas those that retain high levels of mitochondria fission become neurons. Increased mitochondria fission promotes neuronal fate, whereas induction of mitochondria fusion after mitosis redirects daughter cells toward self-renewal. This occurs during a restricted time window that is doubled in human cells, in line with their increased self-renewal capacity. Our data reveal a postmitotic period of fate plasticity in which mitochondrial dynamics are linked with cell fate. [1]: /lookup/doi/10.1126/science.aba9760 |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/288096 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Ryohei Iwata,Pierre Casimir,Pierre Vanderhaeghen. Mitochondrial dynamics in postmitotic cells regulate neurogenesis[J]. Science,2020. |
APA | Ryohei Iwata,Pierre Casimir,&Pierre Vanderhaeghen.(2020).Mitochondrial dynamics in postmitotic cells regulate neurogenesis.Science. |
MLA | Ryohei Iwata,et al."Mitochondrial dynamics in postmitotic cells regulate neurogenesis".Science (2020). |
条目包含的文件 | 条目无相关文件。 |
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