GSTDTAP  > 地球科学
DOI10.1038/s41586-020-2204-1
Retinal innervation tunes circuits that drive nonphotic entrainment to food
Roque, Jose B.; Kuroda, Yusuke; Gottemann, Lucas T.; Sarpong, Richmond
2020-04-16
发表期刊NATURE
ISSN0028-0836
EISSN1476-4687
出版年2020
卷号581期号:7807页码:194-+
文章类型Article
语种英语
国家USA
英文关键词

Daily changes in light and food availability are major time cues that influence circadian timing(1). However, little is known about the circuits that integrate these time cues to drive a coherent circadian output(1-3). Here we investigate whether retinal inputs modulate entrainment to nonphotic cues such as time-restricted feeding. Photic information is relayed to the suprachiasmatic nucleus (SCN)-the central circadian pacemaker-and the intergeniculate leaflet (IGL) through intrinsically photosensitive retinal ganglion cells (ipRGCs)(4). We show that adult mice that lack ipRGCs from the early postnatal stages have impaired entrainment to time-restricted feeding, whereas ablation of ipRGCs at later stages had no effect. Innervation of ipRGCs at early postnatal stages influences IGL neurons that express neuropeptide Y (NPY) (hereafter, IGL(NPY) neurons), guiding the assembly of a functional IGL(NPY)-SCN circuit. Moreover, silencing IGL(NPY) neurons in adult mice mimicked the deficits that were induced by ablation of ipRGCs in the early postnatal stages, and acute inhibition of IGL(NPY) terminals in the SCN decreased food-anticipatory activity. Thus, innervation of ipRGCs in the early postnatal period tunes the IGL(NPY)-SCN circuit to allow entrainment to time-restricted feeding.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000532836000031
WOS关键词INTERGENICULATE LEAFLET ; GANGLION-CELLS ; NUCLEUS ; PROJECTIONS ; GHRELIN ; MICE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/281448
专题地球科学
资源环境科学
气候变化
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GB/T 7714
Roque, Jose B.,Kuroda, Yusuke,Gottemann, Lucas T.,et al. Retinal innervation tunes circuits that drive nonphotic entrainment to food[J]. NATURE,2020,581(7807):194-+.
APA Roque, Jose B.,Kuroda, Yusuke,Gottemann, Lucas T.,&Sarpong, Richmond.(2020).Retinal innervation tunes circuits that drive nonphotic entrainment to food.NATURE,581(7807),194-+.
MLA Roque, Jose B.,et al."Retinal innervation tunes circuits that drive nonphotic entrainment to food".NATURE 581.7807(2020):194-+.
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