A new coronavirus associated with human respiratory disease in China

doi:10.1038/s41586-020-2008-3

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2008-3
	A new coronavirus associated with human respiratory disease in China
	Rollie, Clare 1; Chevallereau, Anne 1; Watson, Bridget N. J.1; Chyou, Te-yuan 2; Fradet, Olivier 1; McLeod, Isobel 1; Fineran, Peter C.3,4; Brown, Chris M.2,4; Gandon, Sylvain 5; Westra, Edze R.1
	2020-01-22
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	579 期号:7798 页码:265-+
文章类型	Article
语种	英语
国家	Peoples R China; Australia
英文关键词	Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health(1-3). Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing(4) of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here ' WH-Human 1' coronavirus (and has also been referred to as ' 2019-nCoV' ). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China(5). This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000518098100002
WOS关键词	MULTIPLE SEQUENCE ALIGNMENT ; SARS-LIKE CORONAVIRUS ; MAXIMUM-LIKELIHOOD ; VIRUS ; BATS ; IDENTIFICATION ; PERFORMANCE ; DIVERSITY ; HKU1
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/280959
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Exeter, ESI, Biosci, Penryn, England; 2.Univ Otago, Dept Biochem, Dunedin, New Zealand; 3.Univ Otago, Dept Microbiol & Immunol, Dunedin, New Zealand; 4.Univ Otago, Genet Otago, Dunedin, New Zealand; 5.Univ Paul Valery Montpellier 3, Univ Montpellier, CEFE, CNRS,EPHE,IRD, Montpellier, France
推荐引用方式 GB/T 7714	Rollie, Clare,Chevallereau, Anne,Watson, Bridget N. J.,et al. A new coronavirus associated with human respiratory disease in China[J]. NATURE,2020,579(7798):265-+.
APA	Rollie, Clare.,Chevallereau, Anne.,Watson, Bridget N. J..,Chyou, Te-yuan.,Fradet, Olivier.,...&Westra, Edze R..(2020).A new coronavirus associated with human respiratory disease in China.NATURE,579(7798),265-+.
MLA	Rollie, Clare,et al."A new coronavirus associated with human respiratory disease in China".NATURE 579.7798(2020):265-+.