Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1002/2016GL072190 |
Global translational reprogramming is a fundamental layer of immune regulation in plants | |
Xu, Guoyong; Greene, George H.; Yoo, Heejin; Liu, Lijing; Marques, Jorge; Motley, Jonathan; Dong, Xinnian | |
2017-05-25 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 545期号:7655页码:487-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | In the absence of specialized immune cells, the need for plants to reprogram transcription to transition from growth-related activities to defence is well understood(1,2). However, little is known about translational changes that occur during immune induction. Using ribosome footprinting, here we perform global translatome profiling on Arabidopsis exposed to the microbe-associated molecular pattern elf18. We find that during this pattern-triggered immunity, translation is tightly regulated and poorly correlated with transcription. Identification of genes with altered translational efficiency leads to the discovery of novel regulators of this immune response. Further investigation of these genes shows that messenger RNA sequence features are major determinants of the observed translational efficiency changes. In the 5' leader sequences of transcripts with increased translational efficiency, we find a highly enriched messenger RNA consensus sequence, R-motif, consisting of mostly purines. We show that R-motif regulates translation in response to pattern-triggered immunity induction through interaction with poly(A)-binding proteins. Therefore, this study provides not only strong evidence, but also a molecular mechanism, for global translational reprogramming during pattern-triggered immunity in plants. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401906500053 |
WOS关键词 | ETHYLENE-INSENSITIVE MUTANTS ; MESSENGER-RNA ; ARABIDOPSIS-THALIANA ; IN-VIVO ; LANDSCAPE ; VECTORS ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/25897 |
专题 | 气候变化 |
作者单位 | Duke Univ, Dept Biol, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Durham, NC 27708 USA |
推荐引用方式 GB/T 7714 | Xu, Guoyong,Greene, George H.,Yoo, Heejin,et al. Global translational reprogramming is a fundamental layer of immune regulation in plants[J]. NATURE,2017,545(7655):487-+. |
APA | Xu, Guoyong.,Greene, George H..,Yoo, Heejin.,Liu, Lijing.,Marques, Jorge.,...&Dong, Xinnian.(2017).Global translational reprogramming is a fundamental layer of immune regulation in plants.NATURE,545(7655),487-+. |
MLA | Xu, Guoyong,et al."Global translational reprogramming is a fundamental layer of immune regulation in plants".NATURE 545.7655(2017):487-+. |
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