Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaz9330 |
Prenatal development of human immunity | |
Jong-Eun Park; Laura Jardine; Berthold Gottgens; Sarah A. Teichmann; Muzlifah Haniffa | |
2020-05-08 | |
发表期刊 | Science
![]() |
出版年 | 2020 |
英文摘要 | The blood and immune systems develop in parallel during early prenatal life. Waves of hematopoiesis separated in anatomical space and time give rise to circulating and tissue-resident immune cells. Previous observations have relied on animal models, which differ from humans in both their developmental timeline and exposure to microorganisms. Decoding the composition of the human immune system is now tractable using single-cell multi-omics approaches. Large-scale single-cell genomics, imaging technologies, and the Human Cell Atlas initiative have together enabled a systems-level mapping of the developing human immune system and its emergent properties. Although the precise roles of specific immune cells during development require further investigation, the system as a whole displays malleable and responsive properties according to developmental need and environmental challenge. |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249716 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Jong-Eun Park,Laura Jardine,Berthold Gottgens,et al. Prenatal development of human immunity[J]. Science,2020. |
APA | Jong-Eun Park,Laura Jardine,Berthold Gottgens,Sarah A. Teichmann,&Muzlifah Haniffa.(2020).Prenatal development of human immunity.Science. |
MLA | Jong-Eun Park,et al."Prenatal development of human immunity".Science (2020). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论