Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II

doi:10.1289/EHP935

GSTDTAP > 资源环境科学

DOI	10.1289/EHP935
	Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II
	James, Peter 1,2,3,4; Bertrand, Kimberly A.5; Hart, Jaime E.2,3,4; Schernhammer, Eva S.1,3,4,6,7; Tamimi, Rulla M.1,3,4; Laden, Francine 1,2,3,4
	2017-08-01
发表期刊	ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN	0091-6765
EISSN	1552-9924
出版年	2017
卷号	125 期号:8
文章类型	Article
语种	英语
国家	USA; Austria
英文摘要	BACKGROUND: Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES: We examined the association between residential outdoor LAN and breast cancer incidence using data from thc nationwide U.S.-based Nurses' Health Study II cohort. METHODS: We followed 109,672 women from 1989 through 2013. Cumulative LAN exposure was estimated using time-vaiying satellite data for a composite of persistent nighttime illumination at 1 km(2) scale for each residence during follow-up. Incident invasive breast cancer cases were confirmed by medical record review. We used Cox proportional hazard models to calculate hazard ratios (HRs) and 95% confidence intervals (Cis), adjusting for anthropometric, reproductive, lifestyle, and socioeconomic risk factors. RESULTS: Over 2,187,425 person-years, we identified 3,549 incident breast cancer cases. Based on a fully adjusted model, the estimated HR for incident breast cancer with an interquartile range (IQR) (31.6 nW/cm(2)/sr) increase in cumulative average outdoor LAN was 1.05 (95% CI: 1.00, 1 An association between LAN and breast cancer appeared to he limited to women who were premenopausal at the time of a case [HR = 1.07 (95% CI: 1.01, 1.14) based on 1,973 cases vs. HR = 1.00 (95% CI: 0.91, 1.09) based on 1,172 cases in postmenopausal women; p-interaction = 0.08]. The LAN breast cancer association was observed only in past and current smokers at the end of follow-up [HR=1.00 (95% CI: 0.94, 1.07) based on 2,215 cases in never smokers; HR = 1.10 (95% CI: 1.01, 1.19) based on 1,034 cases in past smokers vs. HR = 1.21 (95% CI: 1.07, 1.37) for 300 cases in current smokers; p-interaction = 0.081. CONCLUSIONS: Although further work is required to confirm our results and to clarify potential mechanisms, our findings suggest that exposure to residential outdoor light at night may contribute to invasive breast cancer risk.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000413790600020
WOS关键词	AT-NIGHT ; CIRCADIAN DISRUPTION ; CIGARETTE-SMOKING ; PASSIVE SMOKING ; ACTIVE SMOKING ; CO-DISTRIBUTES ; RISK ; REPRODUCIBILITY ; POPULATION ; VALIDITY
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/24204
专题	资源环境科学
作者单位	1.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 2.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 3.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA; 4.Harvard Med Sch, Boston, MA USA; 5.Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA; 6.Med Univ Vienna, Dept Epidemiol, Vienna, Austria; 7.Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
推荐引用方式 GB/T 7714	James, Peter,Bertrand, Kimberly A.,Hart, Jaime E.,et al. Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8).
APA	James, Peter,Bertrand, Kimberly A.,Hart, Jaime E.,Schernhammer, Eva S.,Tamimi, Rulla M.,&Laden, Francine.(2017).Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8).
MLA	James, Peter,et al."Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017).