Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP333 |
DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy | |
Reese, Sarah E.1; Zhao, Shanshan2; Wu, Michael C.3; Joubert, Bonnie R.4; Parr, Christine L.1,5; Haberg, Siri E.6; Ueland, Per Magne7,8; Nilsen, Roy M.9,10; Midttun, Oivind11; Vollset, Stein Emil9,12; Peddada, Shyamal D.2; Nystad, Wenche5; London, Stephanie J.1 | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Norway |
英文摘要 | BACKGROUND: Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport smoking and smokers tend to have lower follow-up rates to repeat questionnaires. Missing, incomplete, or inaccurate data on presence and duration of smoking in pregnancy impairs identification of novel health effects and limits adjustment for smoking in studies of other pregnancy exposures. An objective biomarker in newborns of maternal smoking during pregnancy would be valuable. OBJECTIVES: We developed a biomarker of sustained maternal smoking in pregnancy using common DNA methylation platforms. METHODS: Using a dimension reduction method, we developed and tested a numeric score in newborns to reflect sustained maternal smoking in pregnancy from data on cotinine, a short-term smoking biomarker measured mid-pregnancy, and Illumina450K cord blood DNA methylation from newborns in the Norwegian Mother and Child Cohort Study (MoBa). RESULTS: This score reliably predicted smoking status in the training set (n = 1,057; accuracy = 96%, sensitivity = 80%, specificity = 98%). Sensitivity (58%) was predictably lower in the much smaller test set (n = 221), but accuracy (91%) and specificity (97%) remained high. Reduced birth weight, a well-known effect of maternal smoking, was as strongly related to the score as to cotinine. A three-site score had lower, but acceptable, performance (accuracy(train) = 82%, accuracy(test) = 83%). CONCLUSIONS: Our smoking methylation score represents a promising novel biomarker of sustained maternal smoking during pregnancy easily calculated with Illumina450K or IlluminaEPIC data. It may help identify novel health impacts and improve adjustment for smoking when studying other risk factors with more subtle effects. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400041 |
WOS关键词 | NORWEGIAN MOTHER ; CIGARETTE-SMOKING ; PRENATAL EXPOSURE ; CHILD COHORT ; CPG SITES ; COTININE ; BIRTH ; VALIDATION ; METABOLISM ; MICROARRAY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23948 |
专题 | 资源环境科学 |
作者单位 | 1.NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA; 2.NIEHS, Biostat & Computat Biol Branch, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA; 3.Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA; 4.NIEHS, Populat Hlth Branch, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA; 5.Norwegian Inst Publ Hlth, Dept Chron Dis, Oslo, Norway; 6.Norwegian Inst Publ Hlth, Dept Management & Staff, Oslo, Norway; 7.Univ Bergen, Dept Clin Sci, Bergen, Norway; 8.Haukeland Hosp, Lab Clin Biochem, Bergen, Norway; 9.Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway; 10.Haukeland Hosp, Clin Res Ctr, Bergen, Norway; 11.Bevital AS, Bergen, Norway; 12.Norwegian Inst Publ Hlth, Ctr Dis Burden, Oslo, Norway |
推荐引用方式 GB/T 7714 | Reese, Sarah E.,Zhao, Shanshan,Wu, Michael C.,et al. DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Reese, Sarah E..,Zhao, Shanshan.,Wu, Michael C..,Joubert, Bonnie R..,Parr, Christine L..,...&London, Stephanie J..(2017).DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Reese, Sarah E.,et al."DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论