Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1443 |
Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice | |
Dombret, Carlos1; Capela, Daphne1; Poissenot, Kevin2,3,4,5; Parmentier, Caroline1; Bergsten, Emma1; Pionneau, Cedric6; Chardonnet, Solenne6; Hardin-Pouzet, Helene1; Grange-Messent, Valerie1; Keller, Matthieu2,3,4,5; Franceschini, Isabelle2,3,4,5; Mhaouty-Kodja, Sakina1 | |
2017-09-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:9 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | BACKGROUND: Courtship behavior plays a critical role in attracting females and reproduction success. However, the effects of exposure to a ubiquitous contaminant di(2-ethylhexyl) phthalate (DEHP) on these behaviors and, in particular, on courtship vocalizations have not been examined. OBJECTIVE: The effects of adult exposure to DEHP on courtship and mating behaviors and gonadotropic axis and neural mechanisms involved in DEHP-induced effects were analyzed in male mice. METHODS: Adult C57BL/6J males were orally exposed to DEHP (0, 0.5, 5, and 50 mu g/kg/d) for 4 wk. Olfactory preference, ultrasonic vocalizations (USVs), partner preference and mating, as well as locomotor activity and motor coordination, were measured. The kisspeptin system and testosterone levels were analyzed. Proteomic and molecular studies were conducted on the hypothalamic preoptic nucleus, the key region involved in sexual motivation to vocalize and mate. RESULTS: DEHP at 50?g/kg/d reduced the emission of USVs, whereas lower doses changed the ratio of syllable categories. This was associated with diminished sexual interest of female partners toward males exposed to 5 or 50 mu g/kg/d and increased latency to mate, despite normal olfactory preference. The kisspeptin system and circulating testosterone levels were unaffected. In DEHP-exposed males, proteomic analysis of the preoptic nucleus identified differentially expressed proteins connected to the androgen receptor (AR). Indeed, exposure to 5 or 50 mu g/kg/d of DEHP induced selective AR downregulation in this nucleus and upstream chemosensory regions. The involvement of AR changes in the observed alterations was further supported by the reduced emission of courtship vocalizations in males with disrupted neural AR expression. CONCLUSIONS: These data demonstrate the critical role of neural AR in courtship vocalizations and raises the possibility that the vulnerability of this signaling pathway to exposure to endocrine disrupters may be detrimental for courtship communication and mating in several species. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413792800011 |
WOS关键词 | MESSENGER-RNA EXPRESSION ; ACUTE POSTNATAL EXPOSURE ; MALE SEXUAL-BEHAVIOR ; ANDROGEN-RECEPTOR ; IN-UTERO ; DI-(2-ETHYLHEXYL) PHTHALATE ; ULTRASONIC VOCALIZATIONS ; LACTATIONAL EXPOSURE ; KISSPEPTIN NEURONS ; PERINATAL EXPOSURE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23934 |
专题 | 资源环境科学 |
作者单位 | 1.UPMC Univ Paris 06, Neurosci Paris Seine, Inst Biol Paris Seine, Sorbonne Univ,INSERM,CNRS, Paris, France; 2.Inst Natl Rech Agronom, Unite Mixte Rech 85, Nouzilly, France; 3.Ctr Natl Rech Sci, Unite Mixte Rech 7247, Nouzilly, France; 4.Univ Tours, Tours, France; 5.Inst Francais Cheval & Equitat, Nouzilly, France; 6.UPMC, Sorbonne Univ, Univ Paris 06, Paris, France |
推荐引用方式 GB/T 7714 | Dombret, Carlos,Capela, Daphne,Poissenot, Kevin,et al. Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(9). |
APA | Dombret, Carlos.,Capela, Daphne.,Poissenot, Kevin.,Parmentier, Caroline.,Bergsten, Emma.,...&Mhaouty-Kodja, Sakina.(2017).Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice.ENVIRONMENTAL HEALTH PERSPECTIVES,125(9). |
MLA | Dombret, Carlos,et al."Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice".ENVIRONMENTAL HEALTH PERSPECTIVES 125.9(2017). |
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