Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1011 |
The Saliva Exposome for Monitoring of Individuals' Health Trajectories | |
Bessonneau, Vincent1; Pawliszyn, Janusz1; Rappaport, Stephen M.2 | |
2017-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; USA |
英文摘要 | BACKGROUND: There is increasing evidence that environmental, rather than genetic, factors are the major causes of most chronic diseases. By measuring entire classes of chemicals in archived biospecimens, exposome-wide association studies (EWAS) are being conducted to investigate associations between a myriad of exposures received during life and chronic diseases. OBJECTIVES: Because the intraindividual variability in biomarker levels, arising from changes in environmental exposures from conception onwards, leads to attenuation of exposure disease associations, we posit that saliva can be collected repeatedly in longitudinal studies to reduce exposure measurement errors in EWAS. METHODS: From the literature and an open-source saliva metabolome database, we obtained concentrations of 1,233 chemicals that had been detected in saliva. We connected salivary metabolites with human metabolic pathways and PubMed Medical Subject Heading (MeSH) terms, and performed pathway enrichment and pathway topology analyses. RESULTS: One hundred ninety-six salivary metabolites were mapped into 49 metabolic pathways and connected with human metabolic diseases, central nervous system diseases, and neoplasms. We found that the saliva exposome represents at least 14 metabolic pathways, including amino acid metabolism, TCA cycle, gluconeogenesis, glutathione metabolism, pantothenate and CoA biosynthesis, and butanoate metabolism. CONCLUSIONS: Saliva contains molecular information worthy of interrogation via EWAS. The simplicity of specimen collection suggests that saliva offers a practical alternative to blood for measurements that can be used to characterize individual exposomes. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413791300022 |
WOS关键词 | SOLID-PHASE MICROEXTRACTION ; ALBUMIN TRYPTIC PEPTIDES ; TANDEM MASS-SPECTROMETRY ; FATTY-ACID-BINDING ; LIQUID-CHROMATOGRAPHY ; ORAL FLUID ; HUMAN SERUM ; ALTERNATIVE SPECIMENS ; HEMOGLOBIN LEVEL ; PROTEIN ADDUCTS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23833 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Waterloo, Dept Chem, Waterloo, ON, Canada; 2.Univ Calif Berkeley, Sch Publ Hlth, Ctr Exposure Biol, Berkeley, CA 94720 USA |
推荐引用方式 GB/T 7714 | Bessonneau, Vincent,Pawliszyn, Janusz,Rappaport, Stephen M.. The Saliva Exposome for Monitoring of Individuals' Health Trajectories[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(7). |
APA | Bessonneau, Vincent,Pawliszyn, Janusz,&Rappaport, Stephen M..(2017).The Saliva Exposome for Monitoring of Individuals' Health Trajectories.ENVIRONMENTAL HEALTH PERSPECTIVES,125(7). |
MLA | Bessonneau, Vincent,et al."The Saliva Exposome for Monitoring of Individuals' Health Trajectories".ENVIRONMENTAL HEALTH PERSPECTIVES 125.7(2017). |
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