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DOI | 10.1016/j.foreco.2016.10.045 |
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes | |
Liu, Yang1,2,3; Liu, Jianying1,3; Du, Senyan1; Shan, Chao4,5; Nie, Kaixiao1; Zhang, Rudian1,2; Li, Xiao-Feng6; Zhang, Renli3; Wang, Tao3,7; Qin, Cheng-Feng6; Wang, Penghua8; Shi, Pei-Yong4,5; Cheng, Gong1,3 | |
2017-05-25 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 545期号:7655页码:482-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016)(1-3). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas(1,3). However, the underlying mechanisms through which ZIKV rapidly and explosively spread from Asia to the Americas are unclear. Non-structural protein 1 (NS1) facilitates flavivirus acquisition by mosquitoes from an infected mammalian host and subsequently enhances viral prevalence in mosquitoes(4). Here we show that NS1 antigenaemia determines ZIKV infectivity in its mosquito vector Aedes aegypti, which acquires ZIKV via a blood meal. Clinical isolates from the most recent outbreak in the Americas were much more infectious in mosquitoes than the FSS13025 strain, which was isolated in Cambodia in 2010. Further analyses showed that these epidemic strains have higher NS1 antigenaemia than the FSS13025 strain because of an alanine-to-valine amino acid substitution at residue 188 in NS1. ZIKV infectivity was enhanced by this amino acid substitution in the ZIKV FSS13025 strain in mosquitoes that acquired ZIKV from a viraemic C57BL/6 mouse deficient in type I and II interferon (IFN) receptors (AG6 mouse). Our results reveal that ZIKV evolved to acquire a spontaneous mutation in its NS1 protein, resulting in increased NS1 antigenaemia. Enhancement of NS1 antigenaemia in infected hosts promotes ZIKV infectivity and prevalence in mosquitoes, which could have facilitated transmission during recent ZIKV epidemics. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401906500052 |
WOS关键词 | FLAVIVIRUS NS1 PROTEIN ; PATHOGENESIS ; EMERGENCE ; SERA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23678 |
专题 | 气候变化 |
作者单位 | 1.Tsinghua Univ, Sch Med, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China; 2.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China; 3.Shenzhen Ctr Dis Control & Prevent, SZCDC SUSTech Joint Key Lab Trop Dis, Shenzhen 518055, Guangdong, Peoples R China; 4.Univ Texas Med Branch, Dept Biochem & Mol Biol, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA; 5.Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA; 6.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China; 7.Southern Univ Sci & Technol, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China; 8.New York Med Coll, Sch Med, Dept Microbiol & Immunol, Valhalla, NY 10595 USA |
推荐引用方式 GB/T 7714 | Liu, Yang,Liu, Jianying,Du, Senyan,et al. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes[J]. NATURE,2017,545(7655):482-+. |
APA | Liu, Yang.,Liu, Jianying.,Du, Senyan.,Shan, Chao.,Nie, Kaixiao.,...&Cheng, Gong.(2017).Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes.NATURE,545(7655),482-+. |
MLA | Liu, Yang,et al."Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes".NATURE 545.7655(2017):482-+. |
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