Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP370 |
Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women | |
Vrijens, Karen1; Winckelmans, Ellen1; Tsamou, Maria1; Baeyens, Willy2; De Boever, Patrick1,3; Jennen, Danyel4; de Kok, Theo M.4; Den Hond, Elly3,5; Lefebvre, Wouter3; Plusquin, Michelle1; Reynders, Hans6; Schoeters, Greet3,7,8; Van Larebeke, Nicolas9; Vanpoucke, Charlotte10; Kleinjans, Jos4; Nawrot, Tim S.1,11 | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium; Netherlands; Denmark |
英文摘要 | Background: Particulate matter (PM) exposure leads to premature death, mainly due to respiratory and cardiovascular diseases. Objectives: Identification of transcriptomic biomarkers of air pollution exposure and effect in a healthy adult population. Methods: Microarray analyses were performed in 98 healthy volunteers (48 men, 50 women). The expression of eight sex-specific candidate biomarker genes (significantly associated with PM10 in the discovery cohort and with a reported link to air pollution-related disease) was measured with qPCR in an independent validation cohort (75 men, 94 women). Pathway analysis was performed using Gene Set Enrichment Analysis. Average daily PM2.5 and PM10 exposures over 2-years were estimated for each participant's residential address using spatiotemporal interpolation in combination with a dispersion model. Results: Average long-term PM10 was 25.9 (+/-5.4) and 23.7 (+/-2.3) mu g/m(3) in the discovery and validation cohorts, respectively. In discovery analysis, associations between PM10 and the expression of individual genes differed by sex. In the validation cohort, long-term PM10 was associated with the expression of DNAJB5 and EAPP in men and ARHGAP4 (p = 0.053) in women. AKAP6 and LIMK1 were significantly associated with PM10 in women, although associations differed in direction between the discovery and validation cohorts. Expression of the eight candidate genes in the discovery cohort differentiated between validation cohort participants with high versus low PM10 exposure (area under the receiver operating curve = 0.92; 95% CI: 0.85, 1.00; p = 0.0002 in men, 0.86; 95% CI: 0.76, 0.96; p = 0.004 in women). Conclusions: Expression of the sex-specific candidate genes identified in the discovery population predicted PM10 exposure in an independent cohort of adults from the same area. Confirmation in other populations may further support this as a new approach for exposure assessment, and may contribute to the discovery of molecular mechanisms for PM-induced health effects. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400028 |
WOS关键词 | LONG-TERM EXPOSURE ; HUMAN LUNG-CANCER ; AIR-POLLUTION ; MALIGNANT PHENOTYPE ; PERIPHERAL-BLOOD ; EPITHELIAL-CELLS ; DNA MICROARRAY ; IN-UTERO ; LAND-USE ; DISEASE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22970 |
专题 | 资源环境科学 |
作者单位 | 1.Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium; 2.Free Univ Brussels, Dept Analyt & Environm Chem, Brussels, Belgium; 3.Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium; 4.Maastricht Univ, Dept Toxicogenom, Maastricht, Netherlands; 5.Provincial Inst Hyg, Antwerp, Belgium; 6.Flemish Govt, Environm Nat & Energy Dept, Brussels, Belgium; 7.Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium; 8.Univ Southern Denmark, Inst Publ Hlth, Dept Environm Med, Odense, Denmark; 9.Univ Ghent, Dept Radiotherapy & Nucl Med, Ghent, Belgium; 10.Belgian Interreg Environm Agcy IRCEL, Brussels, Belgium; 11.Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Vrijens, Karen,Winckelmans, Ellen,Tsamou, Maria,et al. Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Vrijens, Karen.,Winckelmans, Ellen.,Tsamou, Maria.,Baeyens, Willy.,De Boever, Patrick.,...&Nawrot, Tim S..(2017).Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Vrijens, Karen,et al."Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
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