Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2716 |
Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study | |
Liu, Wenyu1,2,3; Zhang, Bin4; Huang, Zheng1,2,3; Pan, Xinyun5; Chen, Xiaomei1,2,3; Hu, Chen1,2,3; Liu, Hongxiu1,2,3; Jiang, Yangqian1,2,3; Sun, Xiaojie1,2,3; Peng, Yang1,2,3; Xia, Wei1,2,3; Xu, Shunqing1,2,3; Li, Yuanyuan1,2,3 | |
2018-02-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:2 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | BACKGROUND: Several studies have reported that cadmium (Cd) is associated with type 2 diabetes. However, little is known about Cd exposure and the risk of gestational diabetes mellitus (GDM). OBJECTIVE: We examined the association between Cd body burden in early pregnancy and the risk of GDM. METHODS: We conducted a prospective study of 2,026 pregnant women from a single tertiary medical center between 2013 and 2016 in Wuhan, China. Cd body burden was reflected by Cd concentrations in urine samples collected between gestational weeks 8 and 14. GDM was diagnosed according to International Association of Diabetes and Pregnancy Study Groups Consensus Panel (IADPSG) recommendations. RESULTS: The geometric mean of Cd concentrations in maternal urine of all pregnant women was 0.59 mu g/L. A total of 198 (9.8%) women were diagnosed with GDM. After adjustment for potential confounders, the risk ratios (RRs) of GDM were 1.04 (95% CI: 0.74, 1.44) for the middle tertile of Cd levels and 1.36 (95%: Cl: 0.98, 1.90) for the top tertile compared with the bottom tertile. In addition, we found a significant interaction between fetal sex and maternal Cd levels on the risk of GDM (p for interaction = 0.03). Among women carrying male fetuses, the RR of GDM was 1.86 (95% CI: 1.14, 2.93) for the top tertile of Cd levels compared with the bottom tertile. CONCLUSIONS: To our knowledge, this is the first report of an association between urinary Cd levels in early pregnancy and GDM. Our findings suggest that Cd body burden increases the risk of GDM and that the association may be modified by fetal sex. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000424500800009 |
WOS关键词 | IMPAIRED GLUCOSE-TOLERANCE ; MATERNAL ARSENIC EXPOSURE ; URINARY CADMIUM ; BIOLOGICAL SAMPLES ; TOXIC METALS ; ASSOCIATION ; RISK ; HEALTH ; MECHANISMS ; PREGNANCY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22716 |
专题 | 资源环境科学 |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth HUST, Wuhan, Hubei, Peoples R China; 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan, Hubei, Peoples R China; 4.Wuhan Med & Hlth Ctr Women & Children, Wuhan, Hubei, Peoples R China; 5.Wuhan Ctr Dis Prevent & Control, Dept Environm Hlth & Food Safety, Wuhan, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Wenyu,Zhang, Bin,Huang, Zheng,et al. Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(2). |
APA | Liu, Wenyu.,Zhang, Bin.,Huang, Zheng.,Pan, Xinyun.,Chen, Xiaomei.,...&Li, Yuanyuan.(2018).Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study.ENVIRONMENTAL HEALTH PERSPECTIVES,126(2). |
MLA | Liu, Wenyu,et al."Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study".ENVIRONMENTAL HEALTH PERSPECTIVES 126.2(2018). |
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