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DOI | 10.1073/pnas.1909886116 |
Artificial turf infill associated with systematic toxicity in an amniote vertebrate | |
Elvis Genbo Xu; Nicholas Lin; Rachel S. Cheong; Charlotte Ridsdale; Rui Tahara; Trina Y. Du; Dharani Das; Jiping Zhu; Laura Peña Silva; Agil Azimzada; Hans C. E. Larsson; Nathalie Tufenkji | |
2019-12-10 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
ISSN | 0027-8449 |
出版年 | 2019 |
卷号 | 116期号:50页码:25156-25161 |
英文摘要 | AbstractArtificial athletic turf containing crumb rubber (CR) from shredded tires is a growing environmental and public health concern. However, the associated health risk is unknown due to the lack of toxicity data for higher vertebrates. We evaluated the toxic effects of CR in a developing amniote vertebrate embryo. CR water leachate was administered to fertilized chicken eggs via different exposure routes, i.e., coating by dropping CR leachate on the eggshell; dipping the eggs into CR leachate; microinjecting CR leachate into the air cell or yolk. After 3 or 7 d of incubation, embryonic morphology, organ development, physiology, and molecular pathways were measured. The results showed that CR leachate injected into the yolk caused mild to severe developmental malformations, reduced growth, and specifically impaired the development of the brain and cardiovascular system, which were associated with gene dysregulation in aryl hydrocarbon receptor, stress-response, and thyroid hormone pathways. The observed systematic effects were probably due to a complex mixture of toxic chemicals leaching from CR, such as metals (e.g., Zn, Cr, Pb) and amines (e.g., benzothiazole). This study points to a need to closely examine the potential regulation of the use of CR on playgrounds and artificial fields. |
英文关键词 | artificial turf amniote model tire crumb embryonic development environmental health |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226625 |
专题 | 环境与发展全球科技态势 |
推荐引用方式 GB/T 7714 | Elvis Genbo Xu,Nicholas Lin,Rachel S. Cheong,et al. Artificial turf infill associated with systematic toxicity in an amniote vertebrate[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(50):25156-25161. |
APA | Elvis Genbo Xu.,Nicholas Lin.,Rachel S. Cheong.,Charlotte Ridsdale.,Rui Tahara.,...&Nathalie Tufenkji.(2019).Artificial turf infill associated with systematic toxicity in an amniote vertebrate.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(50),25156-25161. |
MLA | Elvis Genbo Xu,et al."Artificial turf infill associated with systematic toxicity in an amniote vertebrate".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.50(2019):25156-25161. |
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