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DOI | 10.1126/science.aaz0898 |
Functional diversity of human intrinsically photosensitive retinal ganglion cells | |
Mure, Ludovic S.1; Vinberg, Frans2; Hanneken, Anne3; Panda, Satchidananda1 | |
2019-12-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6470页码:1251-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a subset of cells that participate in image-forming and non-image-forming visual responses. Although both functional and morphological subtypes of ipRGCs have been described in rodents, parallel functional subtypes have not been identified in primate or human retinas. In this study, we used a human organ donor preparation method to measure human ipRGCs' photoresponses. We discovered three functional ipRGC subtypes with distinct sensitivities and responses to light. The response of one ipRGC subtype appeared to depend on exogenous chromophore supply, and this response is conserved in both human and mouse retinas. Rods and cones also provided input to ipRGCs; however, each subtype integrated outer retina light signals in a distinct fashion. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000502662500059 |
WOS关键词 | VITAMIN-A ; ACTION SPECTRUM ; MELANOPSIN ; LIGHT ; WAVELENGTH ; MELATONIN ; RESPONSES ; SUBTYPES ; SENSITIVITY ; IRRADIANCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226383 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Salk Inst Biol Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037 USA; 2.Univ Utah, John A Moran Eye Ctr, 65 Mario Capecchi Dr S3140, Salt Lake City, UT 84132 USA; 3.Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA |
推荐引用方式 GB/T 7714 | Mure, Ludovic S.,Vinberg, Frans,Hanneken, Anne,et al. Functional diversity of human intrinsically photosensitive retinal ganglion cells[J]. SCIENCE,2019,366(6470):1251-+. |
APA | Mure, Ludovic S.,Vinberg, Frans,Hanneken, Anne,&Panda, Satchidananda.(2019).Functional diversity of human intrinsically photosensitive retinal ganglion cells.SCIENCE,366(6470),1251-+. |
MLA | Mure, Ludovic S.,et al."Functional diversity of human intrinsically photosensitive retinal ganglion cells".SCIENCE 366.6470(2019):1251-+. |
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