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DOI | 10.1289/EHP54 |
Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice | |
Drummond, David1; Baravalle-Einaudi, Melissa1; Lezmi, Guillaume1; Vibhushan, Shamila1; Franco-Montoya, Marie-Laure1; Hadchouel, Alice1,2,3,4; Boczkowski, Jorge1; Delacourt, Christophe1,2,3,4 | |
2017-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Background: Fetal determinants of airway function, such as in utero exposure to maternal cigarette smoke (CS), may create a predisposition to adult airflow obstruction and chronic obstructive pulmonary disease (COPD) in adulthood. It has been suggested that active smoking in adolescence and preexisting airflow obstruction have synergistic deleterious effects. Objective: We used a mouse model to investigate whether there is a synergistic effect of exposure to CS in utero and during adolescence on lung function. Methods: Female C57Bl/6J mice were exposed to CS or to filtered room air during pregnancy. Exposure to CS began 2 weeks before mating and continued until delivery. After birth, the pups were not exposed to CS until day 21 (D21). Between D21 and D49, corresponding to "adolescence," litters were randomized for an additional 4 weeks of exposure to CS. Lung morphometry, lung mechanics, and the expression of genes involved in senescence were evaluated in different subsets of mice on D21 and D49. Results: In utero exposure to CS induced significant lung function impairment by D21. CS exposure between D21 and D49 induced significant functional impairment only in mice exposed to CS prenatally. On D49, no difference was observed between subgroups in terms of lung p53, p16, p21, and Bax mRNA levels. Conclusions: Our findings suggest that prenatal and adolescent CS exposure have a synergistic effect on lung function in mice. The combined effect did not appear to be a consequence of early pulmonary senescence. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395714400020 |
WOS关键词 | OBSTRUCTIVE PULMONARY-DISEASE ; CIGARETTE-SMOKE ; MATERNAL SMOKING ; RESPIRATORY-FUNCTION ; BIRTH-WEIGHT ; AIRWAY ; PREGNANCY ; EMPHYSEMA ; NICOTINE ; ASTHMA |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22593 |
专题 | 资源环境科学 |
作者单位 | 1.IMRB, INSERM, U955, Equipe 04, 8 Rue Gen Sarrail, F-94000 Creteil, France; 2.AP HP, Pneumol Pediat, Paris, France; 3.Reference Malad Resp Rares, Paris, France; 4.Univ Paris 05, Paris, France |
推荐引用方式 GB/T 7714 | Drummond, David,Baravalle-Einaudi, Melissa,Lezmi, Guillaume,et al. Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(3). |
APA | Drummond, David.,Baravalle-Einaudi, Melissa.,Lezmi, Guillaume.,Vibhushan, Shamila.,Franco-Montoya, Marie-Laure.,...&Delacourt, Christophe.(2017).Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice.ENVIRONMENTAL HEALTH PERSPECTIVES,125(3). |
MLA | Drummond, David,et al."Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice".ENVIRONMENTAL HEALTH PERSPECTIVES 125.3(2017). |
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