Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP661 |
House Dust Endotoxin and Periphera lLeukocyte Counts: Results from Two Large Epidemiologic Studies | |
Fessler, Michael B.1; Carnes, Megan U.2; Salo, Paivi M.1; Wilkerson, Jesse3; Cohn, Richard D.3; King, Debra4; Hoppin, Jane A.5,6; Sandler, Dale P.2; Travlos, Greg4; London, Stephanie J.1,2; Thorne, Peter S.7; Zeldin, Darryl C.1 | |
2017-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: The peripheral leukocyte count is a biomarker of inflammation and is associated with human all-cause mortality. Although causes of acute leukocytosis are well-described, chronic environmental determinants of leukocyte number are less well understood. OBJECTIVES: We investigated the relationship between house dust endotoxin concentration and peripheral leukocyte counts in human subjects. METHODS: The endotoxin leukocyte relationship was evaluated by linear regression in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 (n = 6,254) and the Agricultural Lung Health Study (ALIAS; n = 1,708). In the ALHS, we tested for a gene [Toll-like Receptor 4 (TLR4), encoding the endotoxin receptor]-by-environment interaction in the endotoxin leukocyte relationship using regression models with an interaction term. RESULTS: There is a statistically significant, positive association between endotoxin concentration and total leukocyte number [estimated change, 0.186X10(3)/mu L (95% CI: 0.070, 0.301X10(3)/mu L) per 10-fold change in endotoxin; p = 0.004) in the NHANES. Similar positive associations were found for monocytes, lymphocytes, and neutrophils. Stratified analyses revealed possible effect modification by asthma and chronic obstructive pulmonary disease. We observed similar associations in the ALIAS. For total leukocytes, there was suggestive evidence in the ALHS of a gene-by-environment interaction for minor allele carrier status at the TLR4 haplotype defined by rs4986790 and rs4986791 (interaction p = 0.15). CONCLUSIONS: This is, to our knowledge, the first report of an association between house dust endotoxin and leukocyte count in a national survey. The finding was replicated in a farming population. Peripheral leukocyte count may be influenced by residential cndotoxin exposure in diverse settings. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413786500011 |
WOS关键词 | SCHOOL-AGE-CHILDREN ; BLOOD-CELL COUNT ; INHALED ENDOTOXIN ; AIRBORNE ENDOTOXIN ; CIGARETTE-SMOKE ; UNITED-STATES ; MYOCARDIAL-INFARCTION ; INFLAMMATORY RESPONSE ; ASTHMATIC-PATIENTS ; NATIONAL-SURVEY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22567 |
专题 | 资源环境科学 |
作者单位 | 1.NIEHS, Immun Inflammat & Dis Lab, NIH, DHHS, POB 12233, Res Triangle Pk, NC 27709 USA; 2.NIEHS, Epidemiol Branch, NIH, DHHS, POB 12233, Res Triangle Pk, NC 27709 USA; 3.Social & Sci Syst Inc, Durham, NC USA; 4.NIEHS, Clin Pathol Grp, NIH, DHHS, POB 12233, Res Triangle Pk, NC 27709 USA; 5.North Carolina State Univ, Dept Biol Sci, Raleigh, NC USA; 6.North Carolina State Univ, Ctr Human Hlth & Environm, Raleigh, NC USA; 7.Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Iowa City, IA 52242 USA |
推荐引用方式 GB/T 7714 | Fessler, Michael B.,Carnes, Megan U.,Salo, Paivi M.,et al. House Dust Endotoxin and Periphera lLeukocyte Counts: Results from Two Large Epidemiologic Studies[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(5). |
APA | Fessler, Michael B..,Carnes, Megan U..,Salo, Paivi M..,Wilkerson, Jesse.,Cohn, Richard D..,...&Zeldin, Darryl C..(2017).House Dust Endotoxin and Periphera lLeukocyte Counts: Results from Two Large Epidemiologic Studies.ENVIRONMENTAL HEALTH PERSPECTIVES,125(5). |
MLA | Fessler, Michael B.,et al."House Dust Endotoxin and Periphera lLeukocyte Counts: Results from Two Large Epidemiologic Studies".ENVIRONMENTAL HEALTH PERSPECTIVES 125.5(2017). |
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