Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP5482 |
Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort | |
Inoue, Kosuke1,2; Ritz, Beate1,2,3; Andersen, Stine Linding4,5; Ramlau-Hansen, Cecilia Host6; Hoyer, Birgit Bjerre6; Bech, Bodil Hammer6; Henriksen, Tine Brink7; Bonefeld-Jorgensen, Eva Cecilie8,9; Olsen, Jorn10; Liew, Zeyan11,12 | |
2019-11-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:11 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark; Greenland |
英文摘要 | BACKGROUND: Maternal thyroid hormones are essential for fetal brain development in early gestation. Perfluoroalkyl substances (PFASs) widespread and persistent pollutants have been suggested to interfere with maternal thyroid honnones in the second or third trimesters, but evidence for an association in the early pregnancy period is sparse. OBJECTIVES: Our goal was to evaluate the gestational-week specific associations of maternal thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels with plasma concentrations of six PFAS chemicals in the first and second pregnancy trimester. METHODS: A cross-sectional analysis was conducted using 1,366 maternal blood samples collected between gestational weeks (OWs) 5 and 19 (median, 8 gestational weeks) in the Danish National Birth Cohort (DNBC) during 1996-2002. We estimated the percentage changes of serum TSH and 1T4 levels according to concentrations (in nanograms per milliliter) of six PFAS chemicals modeled as per interquartile range (IQR) increase or by exposure quartiles. Moreover, we contrasted the estimated week-specific TSH or 1T4 levels by PFAS quartile and estimated ORs for binary high or low TSH and ff4 status based on the week-specific distribution according to IQR increase of PFAS. RESULTS: TSH levels followed a ti-curve trend in early pregnancy with a nadir at GW10, whereas ff4 levels were less fluctuated in the samples. There were no apparent associations between any of the PFASs and changes of average TSH or fT4 levels in total samples. In gestational-week specific analyses, we found that the estimated TSH values were higher among the highest perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), periluorohexane sulfonate (PFHxS), and perfluoroheptane sulfonate (PFHpS) quartiles compared with the lower quartiles from GW5 to GW10, but the difference became null or even reversed after GW10. For binary outcomes, perlluorodecanoic acid (PFDA) was associated with high 1T4 status before GW10 = 1.46 (95% Cl 1.04, 2.05)] CONCLUSIONS: We observed some gestational-week specific associations between high exposure to several PFAS and TSH level in early gestations. Further research of the biology and the potential clinical impact regarding thyroid hormones disruptions in early pregnancy is needed. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000500762600003 |
WOS关键词 | NEURODEVELOPMENTAL DISORDERS ; POLYFLUOROALKYL SUBSTANCES ; PERFLUORINATED COMPOUNDS ; PRENATAL EXPOSURE ; DRINKING-WATER ; IODINE INTAKE ; ASSOCIATION ; CHILDHOOD ; POPULATION ; ACIDS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/224623 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA; 2.Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth, Los Angeles, CA USA; 3.Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA; 4.Aalborg Univ Hosp, Dept Endocrinol, Aalborg, Denmark; 5.Aalborg Univ Hosp, Dept Clin Biochem, Aalborg, Denmark; 6.Aarhus Univ, Dept Publ Hlth, Epidemiol Res Unit, Aarhus, Denmark; 7.Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Skejby, Denmark; 8.Aarhus Univ, Dept Publ Hlth, Ctr Arctic Hlth & Mol Epidemiol, Aarhus, Denmark; 9.Greenland Univ, Greenland Ctr Hlth Res, Nuuk, Greenland; 10.Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark; 11.Yale Sch Publ Hlth, Dept Environm Hlth Sci, 60 Coll St, New Haven, CT 06510 USA; 12.Yale Sch Publ Hlth, Yale Ctr Perinatal Pediat & Environm Epidemiol, New Haven, CT USA |
推荐引用方式 GB/T 7714 | Inoue, Kosuke,Ritz, Beate,Andersen, Stine Linding,et al. Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(11). |
APA | Inoue, Kosuke.,Ritz, Beate.,Andersen, Stine Linding.,Ramlau-Hansen, Cecilia Host.,Hoyer, Birgit Bjerre.,...&Liew, Zeyan.(2019).Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,127(11). |
MLA | Inoue, Kosuke,et al."Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 127.11(2019). |
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