Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP5564 |
Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure | |
Iribarne-Duran, Luz M.1; Artacho-Cordon, Francisco1,2,3; Pena-Caballero, Manuela4; Molina-Molina, Jose M.1,2; Jimenez-Diaz, Inmaculada1; Vela-Soria, Fernando1; Serrano, Laura4; Hurtado, Jose A.4; Fernandez, Mariana F.1,2,3; Freire, Carmen1,2; Olea, Nicolas1,2,3,5 | |
2019-11-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:11 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain |
英文摘要 | BACKGROUND: Newborns in neonatal intensive care units (NICUs) arc in contact'ith a variety of medical products whose production might include synthetic chemicals with hormonal activity. OBJECTIVES: Our aim was to assess the content of bisphenol A (BPA) and parabens (PBs) and the hormone-like activities of a subset of medical products commonly used in NICUs in prolonged intimate contact with NICU newborns. METHODS: Fifty-two NICU items were analyzed, determining the concentrations of BPA and PBs [methyl-(MeP), ethyl-(EtP), propyl-(PrP), and butylparaben (BuP)] and using the E-Screen and PALM-luciferase assays to measure the in vitro (anti-)estrogenic and (anti-)androgenic activity, respectively, of the extracts. Items found to have elevated BPA/PB content or hormone-like activities were further extracted using leaching methodologies. RESULTS: BPA was found in three-fifths and PBs in four-fifths of tested NICU items, and 25% and 10% of extracts evidenced estrogenic and anti-androgenic activity, respectively. The highest BPA content was found in the three-way stopcock (>7.000 ng/g), followed by patterned transparent film dressing, gastro-duodenal feeding tubes, sterile gloves, single-lumen umbilical catheters, and intravenous (IV) infusion extension sets (concentrations ranged from 100 to 700 ng/g BPA). A total PB concentration (Y. PBs) >100 ng/g was observed in several items, including light therapy protection glasses, patterned transparent film dressing, winged IV catheters, IV infusion extension sets, and textile tape. The highest estrogenic activity [>450 pM estradiol equivalent (E2cq)I was found in small dummy nipples, three-way stopcocks, and patterned transparent film dressing and the highest anti-androgenic activity [>5 mM procymidone equivalent units per gram (Proccq/g)] in small dummy nipples and three-way stopcocks. DISCUSSION: According to these findings, neonates might be exposed to multiple sources of BPA and PBs in N1CUs via inhalation, dermal, oral, and IV/parenteral routes. There is a need to address the future health implications for these extremely vulnerable patients and to adopt precautionary preventive measures as a matter of urgency. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000500762600005 |
WOS关键词 | GAS-CHROMATOGRAPHY ; CELL-LINE ; BENZOPHENONES ; MIGRATION ; PHTHALATE ; PRODUCTS ; POLYCARBONATE ; TRICLOSAN ; ANDROGEN ; CHILDREN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/224619 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Inst Invest Biosanitaria Ibs GRANADA, Ave Invest 11, E-18016 Granada, Spain; 2.CIBERESP, Madrid, Spain; 3.Univ Granada, Radiol & Phys Med Dept, Granada, Spain; 4.Virgen de las Nieves Univ Hosp, Neonatal Intens Care Unit, Granada, Spain; 5.San Cecilio Univ Hosp, Granada, Spain |
推荐引用方式 GB/T 7714 | Iribarne-Duran, Luz M.,Artacho-Cordon, Francisco,Pena-Caballero, Manuela,et al. Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(11). |
APA | Iribarne-Duran, Luz M..,Artacho-Cordon, Francisco.,Pena-Caballero, Manuela.,Molina-Molina, Jose M..,Jimenez-Diaz, Inmaculada.,...&Olea, Nicolas.(2019).Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure.ENVIRONMENTAL HEALTH PERSPECTIVES,127(11). |
MLA | Iribarne-Duran, Luz M.,et al."Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure".ENVIRONMENTAL HEALTH PERSPECTIVES 127.11(2019). |
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