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DOI | 10.1289/EHP3442 |
Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study | |
Wang, Weiye1; Moroi, Sayoko2; Bakulski, Kelly1; Mukherjee, Bhramar3; Weisskopf, Marc G.4; Schaumberg, Debra5,6,7; Sparrow, David8,9; Vokonas, Pantel S.8,9; Hu, Howard10,11; Park, Sung Kyun1,11 | |
2018-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada |
英文摘要 | BACKGROUND: Oxidative stress may play an important role in the etiology of primary open-angle glaucoma (POAG). The association between risk of POAG and lead exposure, which is an environmental source of oxidative stress, has not been fully investigated yet. OBJECTIVE: Our objective was to determine the association between bone lead-a biomarker of cumulative lead dose (tibia lead) or an endogenous source of stored lead (patella lead)-and incident POAG. METHODS: We examined a prospective cohort of 634 POAG-free men [mean baseline age = 66.8 y of age (SD = 6.7)] from the Normative Aging Study (NAS) who had tibia and patella K X-ray fluorescence lead measurements between 1 January 1991 and 31 December 1999. They also had standard ocular evaluations by NAS optometrists until 31 December 2014. POAG cases were identified by consistent reports of enlarged or asymmetric cup-to-disc ratio together with visual field defect or existence of disc hemorrhage. We used Cox proportional hazards regressions to estimate hazard ratios (HRs) of incident POAG and adjusted survival curves to examine changes in the risk of POAG during follow-up according to bone lead quartiles. RESULTS: We identified 44 incident cases of POAG by the end of follow-up (incidence rate = 74 per 10,000 person-years; median follow-up = 10.6 y). In fully adjusted models, 10-fold increases in patella lead and tibia lead were associated with HRs of 5.06 (95% CI: 1.61, 15.88,p = 0.005) and 3.07 (95% CI: 0.94, 10.0,p = 0.06), respectively. The HRs comparing participants in the third and fourth quartiles with the lowest quartile were 3.41 (95% CI: 1.34, 8.66) and 3.24 (95% CI: 1.22, 8.62) for patella lead (p-for-trend = 0.01), and 3.84 (95% CI: 1.54, 9.55) and 161 (95% CI: 0.95, 7.21) for tibia lead (p-for-trend = 0.02). CONCLUSIONS: Our study provides longitudinal evidence that bone lead may be an important risk factor for POAG in the U.S. population. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000444417500005 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; X-RAY-FLUORESCENCE ; OXIDATIVE STRESS ; TRABECULAR MESHWORK ; OCULAR HYPERTENSION ; CIGARETTE-SMOKING ; SELECTION BIAS ; FAMILY-HISTORY ; AQUEOUS-HUMOR ; HUMAN-DISEASE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22433 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA; 2.Univ Michigan, Kellogg Eye Ctr, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA; 3.Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA; 4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 5.Pharmaceut Prod Dev LLC PPD, Evidera, Real World Evidence, Boston, MA USA; 6.Univ Utah, Sch Med, Dept Ophthalmol & Visual Sci, John A Moran Eye Ctr, Salt Lake City, UT USA; 7.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 8.Vet Affairs Boston Healthcare Syst, Vet Affairs Normat Aging Study, Boston, MA USA; 9.Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA; 10.Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada; 11.Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA |
推荐引用方式 GB/T 7714 | Wang, Weiye,Moroi, Sayoko,Bakulski, Kelly,et al. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(8). |
APA | Wang, Weiye.,Moroi, Sayoko.,Bakulski, Kelly.,Mukherjee, Bhramar.,Weisskopf, Marc G..,...&Park, Sung Kyun.(2018).Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study.ENVIRONMENTAL HEALTH PERSPECTIVES,126(8). |
MLA | Wang, Weiye,et al."Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study".ENVIRONMENTAL HEALTH PERSPECTIVES 126.8(2018). |
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