Evaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection Products (PPPs) under Norwegian conditions

GSTDTAP > 气候变化

	Evaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection Products (PPPs) under Norwegian conditions
	Tollefsen, Knut Erik; Bæk, Kine; Almeida, Ana; Haug, Linn Anette; Norli, Hans; Odenmarck, Sven; Stenrød, Marianne
	2016
出版年	2016
语种	英语
国家	挪威
出版者	Norsk institutt for vannforskning
领域	气候变化
英文摘要	This project evaluated whether the principles of combined toxicity assessment (CTA) and cumulative risk assessment (CRA) can be used to predict the toxicity of ecologically-relevant mixtures of plant protection products (PPPs) in surface waters receiving run-off from Norwegian agricultural areas. A combination of testing solid phase extracts (SPE), whole surface water and a synthetic mixture in an algal bioassay and predicting combined toxicity using CTA models were conducted on selected samples from the Heia catchment (Råde, Norway). The results demonstrated that designing and testing synthetic mixtures on the basis of measured concentrations of PPPs was the best method for the accurate determination of combined toxicity due to confounding factors introduced by whole water and SPE testing. Combined toxicity models based on Concentration Addition (CA) successfully predicted the toxicity of the complex synthetic mixture and verified that a mixture of PPPs acted in an additive manner. Tiered assessment of the cumulative risk of active PPP substances and PPP formulations proposed by the European Food Safety Authority (EFSA) were considered applicable also for the CRA of complex environmental mixtures and could potentially aid the identification of relevant mixtures, risk drivers and susceptible species as input to the assessment and approval of PPPs.
英文关键词	VDP::Matematikk og naturvitenskap: 400 VDP::Mathematics and natural scienses: 400 Kombinerte effekter / Combined effects Kumulativ risikovurdering / Cumulative risk assessment Plantevernmidler / Plant protection products Regulatorisk godkjenning / Regulatory approval
URL	查看原文
来源平台	Center for International Climate and Environmental Research-Oslo (CICERO)
文献类型	科技报告
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/2242
专题	气候变化
推荐引用方式 GB/T 7714	Tollefsen, Knut Erik,Bæk, Kine,Almeida, Ana,et al. Evaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection Products (PPPs) under Norwegian conditions:Norsk institutt for vannforskning,2016.