Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP25 |
A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study | |
Minguez-Alarcon, Lidia1; Sergeyev, Oleg2,3; Burns, Jane S.1; Williams, Paige L.4,5; Lee, Mary M.6,7; Korrick, Susan A.1,8; Smigulina, Luidmila3; Revich, Boris9; Hauser, Russ1 | |
2017-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
![]() |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Russia |
英文摘要 | BACKGROUND: Exposures to endocrine-disrupting chemicals during critical phases of testicular development may be related to poorer semen parameters. However, few studies have assessed the association between childhood organochlorine (OC) exposure and adult semen parameters. OBJECTIVE: We examined whether peripubertal serum OC concentrations are associated with semen parameters among young Russian men. METHODS: From 2003 through 2005, 516 boys were enrolled at age 8-9 years and followed for up to 10 years. Serum OCs were measured in the enrollment samples using high-resolution mass spectrometry. At 18-19 years, 133 young men provided 1 or 2 semen samples (256 samples) collected approximately 1 week apart, which were analyzed for volume, sperm concentration, and motility. Unadjusted and adjusted linear mixed models were used to examine the associations of quartiles of lipid-standardized concentrations of dioxins [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated dibenzo-p-dioxins (PCDDs)], furans, polychlorinated biphenyls (PCBs), and -corresponding toxic equivalents (TEQs) with semen parameters. RESULTS: The median (range) for TCDD was 2.9 (0.4-12.1) pg/g lipid and PCDD TEQ was 8.7 (1.0-36.0) pg TEQ/g lipid. Higher quartiles of TCDD and PCDD TEQs were associated with lower sperm concentration, total sperm count, and total motile sperm count (p-trends <= 0.05). The highest quartile of peripubertal serum TCDD concentrations was associated with a decrease (95% CI) of 40% (18, 66%), 29% (3, 64%), and 30% (2, 70%) in sperm concentration, total sperm count, and total motile sperm count, respectively, compared with the lowest quartile. Similar associations were observed for serum PCDD TEQs with semen parameters. Serum PCBs, furans, and total TEQs were not associated with semen parameters. CONCLUSION: Higher peripubertal serum TCDD concentrations and PCDD TEQs were associated with poorer semen parameters. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395714400029 |
WOS关键词 | POLYCHLORINATED-BIPHENYLS ; DIOXIN EXPOSURE ; QUALITY ; POPULATION ; PUBERTY ; PCBS ; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ; PESTICIDES ; RECEPTOR ; GROWTH |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22364 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave, Boston, MA 02115 USA; 2.Russian Acad Sci, Dept Genom & Human Genet, Vavilov Inst Gen Genet, Moscow, Russia; 3.Chapaevsk Med Assoc, Chapaevsk, Samara Region, Russia; 4.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA; 5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 6.Univ Massachusetts, Sch Med, Dept Pediat, Pediat Endocrine Div, Worcester, MA USA; 7.Univ Massachusetts, Sch Med, Pediat Endocrine Div, Dept Cell & Dev Biol, Worcester, MA USA; 8.Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA; 9.Russian Acad Sci, Inst Forecasting, Moscow, Russia |
推荐引用方式 GB/T 7714 | Minguez-Alarcon, Lidia,Sergeyev, Oleg,Burns, Jane S.,et al. A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(3). |
APA | Minguez-Alarcon, Lidia.,Sergeyev, Oleg.,Burns, Jane S..,Williams, Paige L..,Lee, Mary M..,...&Hauser, Russ.(2017).A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(3). |
MLA | Minguez-Alarcon, Lidia,et al."A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.3(2017). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论